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Effects of a New Benzimidazole Derivative on Generative Function of Female Rats

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The effects of a new thietanylbenzimidazole derivative (K-134) on estrous cycles, conception processes, and sexual behavior of female rats were studied. Two-week oral treatment with K-134 in doses of 5 and 50 mg/kg shortened the estrus phase and prolonged proestrus. Changes in sexual behavior were presented by activation of receptive sexual motivations without affecting proceptive motivations. The pregnancy and fertility indexes in experimental females after mating with intact males increased and pre- and postimplantation embryonic death decreased.

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Authors and Affiliations

  1. Research Institute of Pharmacology, Volgograd State Medical University, Volgograd, Russia

    E. A. Kuzubova, L. I. Bugaeva, S. A. Sergeeva, V. I. Petrov, V. A. Kataev, I. V. Kharlamov & M. V. Mal’tsev

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  1. E. A. Kuzubova
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  2. L. I. Bugaeva
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  3. S. A. Sergeeva
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  4. V. I. Petrov
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  5. V. A. Kataev
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  6. I. V. Kharlamov
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  7. M. V. Mal’tsev
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Corresponding author

Correspondence to L. I. Bugaeva.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 159, No. 5, pp. 594-596, May, 2015

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Kuzubova, E.A., Bugaeva, L.I., Sergeeva, S.A. et al. Effects of a New Benzimidazole Derivative on Generative Function of Female Rats. Bull Exp Biol Med 159, 635–637 (2015). https://doi.org/10.1007/s10517-015-3034-2

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  • DOI: https://doi.org/10.1007/s10517-015-3034-2

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