The effects of infliximab, an anticytokine drug, on the course of inflammatory process was studied on the model of ulcerative colitis induced by injection of picrylsulfonic acid. Infliximab prevented the development of toxic dilatation and a drop of bioelectric activity of smooth muscles via maintenance of activity of the intramural nervous system neurons.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 153, No. 6, pp. 872-875, June, 2012
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Lazebnik, L.B., Lychkova, A.E. & Knyazev, O.V. Treatment of Experimental Ulcerative Colitis. Bull Exp Biol Med 153, 890–893 (2012). https://doi.org/10.1007/s10517-012-1852-z
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DOI: https://doi.org/10.1007/s10517-012-1852-z