The expression of markers of undifferentiated CD5+ cells, B cells, T-killer/suppressors, and T-helpers was verified by immunohistochemical methods in the thymuses of elderly, senile, and long-lived humans. The counts of CD5+ cells in the thymus progressively decreased with age. Positive correlations between the counts of CD5+ cells and differentiated T cells were detected. The capacity of CD5+ thymocytes to differentiate into T-killer/suppressors decreased with age.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 151, No. 5, pp. 569–572, May, 2011
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Khavinson, V.K., Linkova, N.S., Polyakova, V.O. et al. Age-Specific Dynamics of Human Thymus Immune Cell Differentiation. Bull Exp Biol Med 151, 631–633 (2011). https://doi.org/10.1007/s10517-011-1401-1
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DOI: https://doi.org/10.1007/s10517-011-1401-1