The effect of Dicarbamin preparation on hemopoiesis suppressed with cyclophosphamide was studied in animal experiments. It was shown that Dicarbamin produced a protective effect on granulocytic hemopoietic steam. This property of the preparation is determined by both protection of immature granulocytic cells at early terms after cytostatic treatment and more active maturation of neutrophils in the bone marrow due to enhanced secretion of humoral factors by elements of hemopoietic environment at late terms of the experiment.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
M. B. Bychkov, N. S. Besova, S. V. Topchieva, et al., Vopr. Onkol., 55, No. 5, 627–633 (2009).
M. L. Gershanovich and L. V. Filatova, Ibid., 53, No. 5, 589–595 (2007).
E. D. Goldberg, A. M. Dygai, and V. V. Zhdanov, Vestn. Ross. Akad. Med. Nauk., No. 10, 6–10 (1998).
E. D. Goldberg, A. M. Dygai, and V. V. Zhdanov, Role of Hemopoiesis-Inducing Microenvironment in the Regulation of Hemopoiesis in Cytostatic Myelosupressions [in Russian], Tomsk (1999).
E. D. Goldberg, A. M. Dygai, and V. P. Shakhov, Methods of Tissue Culture in Hematology [in Russian], Tomsk (1992).
G. F. Lakin, Biometry [in Russian], Moscow (1973).
Antitumor Chemotherapy, Ed. N. I. Perevodchikova [in Russian], Moscow (1996).
I. D. Treshchalin, D. A. Bodyagin, E. R. Pereverzeva, et al., Vopr. Onkol., 55, No. 6, 769–744 (2009).
A. A. Yarilin, Pat. Fiziol., No. 2, 25–29 (1998).
B. I. Lord, H. Gurney, J. Chang, et al., Int. J. Cancer, 50, No. 1, 26–31 (1992).
L. S. Lessin and M. Mittelman, Hematol. Oncol. Clin. North Am., 8, No. 5, 993–1009 (1994).
M. A. Moore, K. Welte, S. Gabrilove, and L. M. Souzal, Haematol. Blood Transfus., 31, 210–220 (1987).
Y. K. Nguyen, J. Fla. Med. Assoc., 81, No. 7, 467–469 (1994).
M. L. Patchen and T. J. MacVittie, Int. J. Immunopharmacol., 7, No. 6, 923–932 (1985).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 150, No. 9, pp. 312–316, September, 2010
Rights and permissions
About this article
Cite this article
Nebolsin, V.E., Zhdanov, V.V., Zyuzkov, G.N. et al. Mechanisms of Protective Effect of Dicarbamin on the Blood System in Cytostatic Treatment. Bull Exp Biol Med 150, 343–347 (2011). https://doi.org/10.1007/s10517-011-1138-x
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-011-1138-x