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Posttraumatic Activity of Signal Pathways of Nuclear Factor κB in Mature Sensory Neurons

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Bulletin of Experimental Biology and Medicine Aims and scope

The aim of this study was to clear out whether injury to the peripheral nerve leads to activation of nuclear factor κB in mature spinal ganglia. Analysis of matrix RNA of nuclear factor κB-dependent genes (monocyte chemoattractant protein MCP-1 and inhibitor of nuclear factor κB IκBα) showed different levels of expression of these genes in the spinal ganglia in vivo after axotomy and in vitro after TNF-α stimulation. On the other hand, DNA-binding activity of nuclear factor κB increased in the spinal ganglia 6 h after axotomy and after 10-min incubation of sensory neuron culture with TNF-α. These data attest to possible involvement of nuclear factor κB in the posttraumatic regulation of gene transcription in spinal ganglion cells.

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Authors and Affiliations

  1. Department of Histology and Embryology, Pediatric Faculty, Russian State Medical University, Moscow, Russia

    S. V. Gushchina & O. V. Volkova

  2. Center of Neurosciences, Institute of Cellular and Molecular Science, Queen Mary’s School of Medicine and Dentistry, University of London, London, United Kingdom

    C. B. Magoulas, N. Yousaf & P. M. Richardson

Authors
  1. S. V. Gushchina
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  2. C. B. Magoulas
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  3. N. Yousaf
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  4. P. M. Richardson
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  5. O. V. Volkova
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Corresponding author

Correspondence to S. V. Gushchina.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 149, No. 4, pp. 460–464, April, 2010

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Gushchina, S.V., Magoulas, C.B., Yousaf, N. et al. Posttraumatic Activity of Signal Pathways of Nuclear Factor κB in Mature Sensory Neurons. Bull Exp Biol Med 149, 474–478 (2010). https://doi.org/10.1007/s10517-010-0974-4

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  • DOI: https://doi.org/10.1007/s10517-010-0974-4

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