Cytogenetic analysis of 13 mesenchymal stem cell cultures isolated from normal human adipose tissue was carried out at different stages of culturing. The incidence of chromosomes 6, 8, 11, and X aneuploidy and polyploidy was studied by fl uorescent in situ hybridization. During the early passages, monosomal cells were more often detected than trisomal ones. A clone with chromosome 6 monosomy was detected in three cultures during late passages.
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Translated from Kletochnye Tehnologii v Biologii i Medicine, No. 3, pp. 123–127, July, 2009
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Buyanovskaya, O.A., Kuleshov, N.P., Nikitina, V.A. et al. Spontaneous Aneuploidy and Clone Formation in Adipose Tissue Stem Cells during Different Periods of Culturing. Bull Exp Biol Med 148, 109–112 (2009). https://doi.org/10.1007/s10517-009-0647-3
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DOI: https://doi.org/10.1007/s10517-009-0647-3