Abstract
An experimental dosage form of rubomycin is developed: the drug is incorporated in absorbable polymeric (polyhydroxybutyrate) matrix in the form of microparticles. Antitumor efficiency of this rubomycin dosage form was studied in laboratory mice with transplanted Ehrlich ascitic carcinoma. Rubomycin deposited in polymeric microparticles exhibited pronounced antitumor activity, inhibited the proliferative activity of Ehrlich ascitic carcinoma, and improved survival of mice with tumors. This dosage form of the drug can be used for local injections.
References
F. I. Ataullakhanov, T. V. Batasheva, and V. M. Vitvitskii, Antibiot. Khimioter., 39, No. 9–10, 26–29 (1993).
T. G. Volova, V. I. Sevast’yanov, and E. I. Shishatskaya, Polyhydroxylalcanoates: Biodegraded Polymers for Medicine [in Russian], Ed. V. I. Shumakov, Krasnoyarsk (2006).
A. M. Genin, A. E. Il’in, A. S. Kaplanskii, et al., Aviakosm. Ekol. Med., 35, No. 4, 14–20 (2001).
BIOPLASTOTAN Trademark, Registration Certificate No. 315652, Federal Institute of Patent Expert Evaluations, application No. 2006703271/50, priority of 15.02.06. MKTU Classes: 01, 05, 10.
E. I. Shishatskaya, A. V. Zhemchugova, and T. G. Volova, Antibiot. Khimioter., Nos. 2–3, 3–14 (2005).
E. I. Shishatskaya and A. Goreva, Perspektivnye Materialy, No. 4, 65–70 (2006).
D. Y. Furgeson, M. R. Dreher, and A. Chilkoti, J. Control Release, 110, No. 2, 362–369 (2006).
D. A. Gewirtz, Biochem. Pharmacol., 57, No. 7, 727–741 (1999).
G. A. Husseini, N. Y. Rapoport, D. A. Christensen, et al., Colloid Surf. B: Bionterf., 24, No. 3, 253–264 (2002).
J. Kost and R. Langer, Adv. Drug Deliv. Rev., 46, Nos. 1–3, 125–148 (2001).
E. S. Lee, K. Na, and Y. H. Bae, J. Control Release, 103, No. 2, 405–418 (2005).
R. Lin, L. Shing, and C. H. Wang, Biomaterials, 26, No. 21, 4476–4485 (2005).
S. Q. Liu, Y. W. Tong, and Yi. Y. Yang, Ibid., 26, No. 24, 5064–5074 (2005).
J. L. West, Nat. Mater., 2, No. 11, 709–710 (2003).
Author information
Authors and Affiliations
Corresponding author
Additional information
__________
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 145, No. 3, pp. 333–336, March, 2008
Rights and permissions
About this article
Cite this article
Shishatskaya, E.I., Goreva, A.V., Voinova, O.N. et al. Evaluation of antitumor activity of rubomycin deposited in absorbable polymeric microparticles. Bull Exp Biol Med 145, 358–361 (2008). https://doi.org/10.1007/s10517-008-0091-9
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-008-0091-9