Abstract
Two-staged technology for obtaining polyclonal T cell vaccine intended for the treatment of rheumatoid arthritis is described. Stage 1 includes antigen-dependent cultural selection of patient’s T cells and stage 2 consists in their reproduction in the needed amounts by nonspecific mitogenic stimulation. T cell vaccination induces an effective specific anti-idiotypic immune response against T cells reactive to joint antigens. Vaccine therapy significantly reduces plasma level of IFN-γ and increases IL-4 level. The results indicate immunological efficiency and safety of polyclonal T cell vaccine in patients with rheumatoid arthritis.
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Translated from Kletochnye Tehnologii v Biologii i Medicine, No. 4, pp. 221–225, October, 2007
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Ivanova, I.P., Seledtsov, V.I., Seledtsov, D.V. et al. Characterization of immunogenic properties of polyclonal T cell vaccine intended for the treatment of rheumatoid arthritis. Bull Exp Biol Med 144, 630–634 (2007). https://doi.org/10.1007/s10517-007-0391-5
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DOI: https://doi.org/10.1007/s10517-007-0391-5