Abstract
The sensitivity of detection of anticholinesterase compounds (e.g. tacrine) by the biochemical method significantly increased when fluorogenic compound N-(4-(7-diethylamino-4-methylcoumarine-3-yl)phenyl)maleimide was used instead of Ellman’s reagent. A kinetic fluorescent method for evaluating cholinesterase inhibitors is proposed.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 142, No. 12, pp. 710–711, December, 2006
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Gainullina, E.T., Kondratyev, K.V., Ryzhikov, S.B. et al. Fluorescent method for evaluation of cholinesterase inhibitors. Bull Exp Biol Med 142, 751–752 (2006). https://doi.org/10.1007/s10517-006-0469-5
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DOI: https://doi.org/10.1007/s10517-006-0469-5