Skip to main content
SpringerLink
Log in

Damage to erythrocyte membranes as the mechanism for acrylate toxicity

  • Pharmacology and Toxicology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Acute poisoning with acrylates (acrylamide and acrylonitrile) was associated with damage to erythrocyte membranes: early stages of acrylamide poisoning were characterized by impairment of the acid resistance of erythrocytes, while later terms of acrylate intoxication were accompanied by condensation of erythrocyte membranes. Activation of lipid peroxidation in blood plasma and erythrocytes was observed during the early stage of intoxication, while at later terms LPO intensity in erythrocytes decreased.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Acrylamide. Hygienic Criteria for Environmental Health [in Russian], Geneva (1987).

  2. Acrylamide. Hygienic Criteria for Environmental Health [in Russian], Geneva (1989).

  3. I. I. Gitel’zon and I. A. Terskov, Erythrograms as the Method for Clinical Study of Blood [in Russian], Krasnoyarsk (1959).

  4. S. N. Golikov, I. V. Sanotskii, and L. A. Tiunov, General Mechanisms of Toxicity [in Russia], Moscow (1986).

  5. V. V. Ivanov, Yu. V. Kotlovskii, L. G. Klimatskaya, et al., Molecular and Cellular Mechanisms for Toxicity of Xenobiotics and Occupational and Ecological Diseases [in Russian], Novosibirsk (2004).

  6. V. V. Men’shikov, Laboratory Methods of Studies in Clinical Practice [in Russian], Moscow (1987).

  7. T. N. Sniedze and V. A. Vasarinya, Experimental Study of Pathological Processes [in Russian], Riga (1988), pp. 67–72.

  8. Modern Biochemical Methods [in Russian], Moscow (1977).

  9. F. C. Jager, Nutr. Dieta. Eur. Rev. Nutr. Diet., 10, No. 3, 215–223 (1968).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Hygiene, Krasnoyarsk Medical Academy, Russian Federal Agency for Health Protection and Social Development, Russia

    M. M. Tarskikh

Authors
  1. M. M. Tarskikh
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

__________

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 142, No. 12, pp. 646–648, December, 2006

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tarskikh, M.M. Damage to erythrocyte membranes as the mechanism for acrylate toxicity. Bull Exp Biol Med 142, 690–692 (2006). https://doi.org/10.1007/s10517-006-0452-1

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-006-0452-1

Key Words

Search

Navigation