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Proliferative activity of retinal vascular cells in newborn rat at different oxygenation modes

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Abstract

We evaluated the relationship between the percentage of oxygen in inhaled air and alternation of this parameter and proliferative activity of cells in retinal vessels of normal newborn rats. The relationships between these parameters and the mean diameter of retinal vessels were evaluated. The study was carried out on total retinal preparations and tangential sections of the retina by the immunoperoxidase and immunofluorescent methods. Hypoxia and hyperoxia significantly suppressed proliferative activity, while alternation of hyperoxia and normoxia significantly increased both proliferative activity of vascular cells and the mean diameter of retinal vessels.

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Authors and Affiliations

  1. Institute of Ocular Diseases, Russian Academy of Medical Sciences, Russia

    S. V. Sdobnikova, S. E. Avetisov & B. A. Gavrilova

  2. Institute of Molecular Medicine, I. M. Setchenov Moscow Medical Academy, Russia

    A. A. Ivanov & A. V. Kuznetsova

  3. Institute of Gene Biology, Russian Academy of Sciences, Russia

    L. I. Korochkin

  4. A. N. Severtsov Institute of Problems of Ecology and Evolution, Russian Academy of Sciences, Moscow

    A. V. Revishchin

Authors
  1. S. V. Sdobnikova
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  2. A. A. Ivanov
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  3. S. E. Avetisov
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  4. B. A. Gavrilova
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  5. A. V. Revishchin
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  6. A. V. Kuznetsova
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  7. L. I. Korochkin
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Corresponding author

Correspondence to S. V. Sdobnikova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 142, No. 10, pp. 475–477, October, 2006

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Sdobnikova, S.V., Ivanov, A.A., Avetisov, S.E. et al. Proliferative activity of retinal vascular cells in newborn rat at different oxygenation modes. Bull Exp Biol Med 142, 490–492 (2006). https://doi.org/10.1007/s10517-006-0400-0

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  • DOI: https://doi.org/10.1007/s10517-006-0400-0

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