Abstract
Long-lasting effects of new Russian psychotropic drugs Noopept and Afobazol on active avoidance conditioning and formation of learned helplessness neurosis were studied on an original experimental model in rats. Noopept eliminated the manifestations of learned helplessness after long-term (21-day) treatment by increasing the percent of trained animals. Afobazol was low effective in preventing manifestations of learned helplessness, but if used for a long time, it reduced the incidence of learned helplessness development by increasing the percent of untrained animals.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
T. A. Voronina, Pharmacology of Nootropes (Experimental and Clinical Study) [in Russian], Moscow (1989).
T. A. Voronina and S. B. Seredenin, Eksp. Klin. Farmakol., 61, No. 4, 3–10 (1998).
G. M. Molodavkin, G. G. Borlikova, et al., Ibid., 63, No. 2, 9–11 (2000).
A. B. Saltykov, A. V. Toloknov, and N. K. Khitrov, Behavior and Indefinite Environment [in Russian], Moscow (1996).
A. B. Saltykov, A. V. Toloknov, and N. K. Khitrov, Pat. Fiziol., Nos. 5–6, 5–7 (1997).
S. B. Seredenin, T. A. Voronina, R. U. Ostrovskaya, et al., Manual of Experimental (Preclinical) Studies of New Drugs [in Russian], Moscow (2000), pp. 126–159.
A. A. Uyanaev, V. P. Fisenko, and N. K. Khitrov, Byull. Eksp. Biol. Med., 136, No. 8, 187–189 (2003).
Author information
Authors and Affiliations
Additional information
__________
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 142, No. 8, pp. 167–169, August, 2006
Rights and permissions
About this article
Cite this article
Uyanaev, A.A., Fisenko, V.P. Studies of long-term noopept and afobazol treatment in rats with learned helplessness neurosis. Bull Exp Biol Med 142, 202–204 (2006). https://doi.org/10.1007/s10517-006-0327-5
Received:
Issue Date:
DOI: https://doi.org/10.1007/s10517-006-0327-5