Abstract
We studied the effects of four synthetic amides of betulonic acid containing amino acid fragments (d,l-α-alanine, β-alanine, and their methyl esters) on the rate of growth and metastatic dissemination of transplantable Lewis lung carcinoma in C57Bl/6 mice. The test compounds were administered intragastrically in a single dose of 500 mg/kg. 3-[-oxo-20(29)-lupen-28-oilamino]-propionic acid suppressed primary tumor growth (by 26%) and decreased the number of lung metastases (by more than 2 times). Antitumor and antimetastatic activity of triterpenoids decreased after methylation of the amino acid fragment in betulonic acid.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 142, No. 7, pp. 78–81, July, 2006
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Sorokina, I.V., Tolstikova, T.G., Zhukova, N.A. et al. Antitumor and antimetastatic effects of betulonic acid amides in mice with transplantable Lewis carcinoma. Bull Exp Biol Med 142, 69–72 (2006). https://doi.org/10.1007/s10517-006-0294-x
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DOI: https://doi.org/10.1007/s10517-006-0294-x