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Disturbances in hormonal regulation of vascular tone during traumatic shock

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Abstract

Changes in hormonal regulation of the vascular tone in Wistar rats were studied on Cannon model of traumatic shock. The pressor response to angiotensin II decreased by 30–40% 3 h after the incidence of trauma. The reaction to vasopressin remained unchanged. However, phenylephrine in medium and high doses produced a more pronounced pressor response under these conditions. One day after trauma we revealed a decrease in vascular sensitivity not only to angiotensin II, but also to vasopressin and α1-adrenoceptor agonist phenylephrine. The vascular response was observed only after treatment with phenylephrine in maximum doses. Traumatic shock was accompanied by inverse response to serotonin: hypertensive effect instead of blood pressure drop. Our results show that traumatic shock is accompanied by specific changes in vascular reactivity.

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Authors and Affiliations

  1. Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Russia

    L. M. Kozhevnikova & P. V. Avdonin

  2. N. K. Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow

    P. V. Avdonin

Authors
  1. L. M. Kozhevnikova
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  2. P. V. Avdonin
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Correspondence to P. V. Avdonin.

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Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 141, No. 5, pp. 511–514, May, 2006

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Kozhevnikova, L.M., Avdonin, P.V. Disturbances in hormonal regulation of vascular tone during traumatic shock. Bull Exp Biol Med 141, 574–577 (2006). https://doi.org/10.1007/s10517-006-0224-y

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  • DOI: https://doi.org/10.1007/s10517-006-0224-y

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