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Targeting mitochondria as a therapeutic anti-gastric cancer approach

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Abstract

Gastric cancer is regarded as the fifth most common cancer globally but the third most common cancer death. Although systemic chemotherapy is the primary treatment for advanced gastric cancer patients, the outcome of chemotherapy is unsatisfactory. Novel therapeutic strategies and potential alternative treatments are therefore needed to overcome the impact of this disease. At a cellular level, mitochondria play an important role in cell survival and apoptosis. A growing body of studies have shown that mitochondria play a central role in the regulation of cellular function, metabolism, and cell death during carcinogenesis. Interestingly, the impact of mitochondrial dynamics, including fission/fusion and mitophagy, on carcinogenesis and cancer progression has also been reported, suggesting the potential targeting of mitochondrial dynamics for the treatment of cancer. This review not only comprehensively summarizes the homeostasis of gastric cancer cells, but the potential therapeutic interventions for the targeting of mitochondria for gastric cancer therapy are also highlighted and discussed.

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Funding

This work was supported by the NSTDA Research Chair grant from the National Science and Technology Development Agency Thailand (NC), The National Research Council of Thailand 2563NRCT321511 (KS), the Chiang Mai University Fundamental Fund (KS), the Senior Research Scholar grant from the National Research Council of Thailand (SCC), and the Chiang Mai University Center of Excellence Award (NC).

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Authors and Affiliations

  1. Division of Gastrointestinal Surgery and Endoscopy, Department of Surgery, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand

    Peticha Tanprasert & Sirikan Limpakan (Yamada)

  2. Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand

    Siriporn C. Chattipakorn, Nipon Chattipakorn & Krekwit Shinlapawittayatorn

  3. Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Chiang Mai, 50200, Thailand

    Siriporn C. Chattipakorn, Nipon Chattipakorn & Krekwit Shinlapawittayatorn

  4. Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand

    Nipon Chattipakorn & Krekwit Shinlapawittayatorn

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  1. Peticha Tanprasert
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  2. Sirikan Limpakan (Yamada)
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  3. Siriporn C. Chattipakorn
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  4. Nipon Chattipakorn
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  5. Krekwit Shinlapawittayatorn
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All authors contributed to the conception. Literature search and data collection were performed by PT. The first draft of the manuscript was written by PT and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Krekwit Shinlapawittayatorn.

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Tanprasert, P., Limpakan (Yamada), S., Chattipakorn, S.C. et al. Targeting mitochondria as a therapeutic anti-gastric cancer approach. Apoptosis 27, 163–183 (2022). https://doi.org/10.1007/s10495-022-01709-0

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