Abstract
This study examined the hypothesis that HIV-related stigma mediates the effect of alcohol use on health-related quality of life (HRQoL) among alcohol consuming Indian men living with HIV (PLWH). The study used baseline data from a randomized controlled clinical trial entitled ‘Alcohol and ART adherence: Assessment, Intervention, and Modeling in India. Participants completed surveys assessing demographic characteristics, alcohol use, HIV-related stigma, HRQoL. Mediation analysis was conducted to establish the mediation effect of HIV-related stigma on the relationship between alcohol use and HRQoL. The final mediation model showed that the effect of alcohol use on HRQoL were partially mediated by overall HIV-related stigma. Specially, 27.1% of the effects of alcohol use on HRQoL was mediated through overall HIV stigma. In the HIV stigma subdomain analyses, negative self-image mediated 14% and concerns with public attitudes (anticipated stigma) mediated 17.3% of the effect of alcohol use on HRQoL respectively. The findings suggest that efforts to reduce the negative impact of alcohol use on HRQoL and improve HRQoL among PLWH should include interventions addressing both alcohol use and specific forms of HIV-related stigma.
Resumen
Este estudio examinó la hipótesis de que el estigma relacionado con el VIH mediaría el efecto del consumo de alcohol en la calidad de vida relacionada con la salud entre hombres indios que consumen alcohol y viven con VIH. El estudio utilizó datos de línea base de un ensayo clínico aleatorizado controlado titulado "Consumo de alcohol y adherencia al TAR: evaluación, intervención y modelización en India". Los participantes completaron encuestas que evaluaron características demográficas, consumo de alcohol, estigma relacionado con el VIH y calidad de vida relacionada con la salud (CVRS). Se realizó un análisis de mediación para establecer el efecto de la mediación del estigma relacionado con el VIH en la relación entre el consumo de alcohol y la CVRS. El modelo final de mediación mostró que el efecto del consumo de alcohol en la CVRS fue parcialmente mediado por el estigma general relacionado con el VIH. Específicamente, el 27,1% de los efectos del consumo de alcohol en la CVRS se medió a través del estigma general relacionado con el VIH. En los análisis de subdominios del estigma del VIH, la imagen negativa de sí mismo medió el 14% y las preocupaciones sobre las actitudes públicas (estigma anticipado) mediaron el 17,3% del efecto del consumo de alcohol en la CVRS, respectivamente. Los resultados sugieren que los esfuerzos para reducir el impacto negativo del consumo de alcohol en la CVRS y mejorar la CVRS entre las personas que viven con VIH deberían incluir intervenciones que aborden tanto el consumo de alcohol como formas específicas de estigma relacionado con el VIH.
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Data Availability
The data presented in this study are available on request from the corresponding author.
Code Availability
The statistical code used in this study are available on request from the corresponding author.
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Acknowledgements
The authors acknowledge the valuable contributions of the project partners in India, investigators, and participants.
Funding
NIH/NIAAA Grant: U01-AA021990R. Data in this manuscript were collected by the project entitled ‘Alcohol and ART adherence: Assessment, Intervention, and Modeling in India’. PD/principal investigator: Stephen L. Schensul, University of Connecticut Health, Farmington, Connecticut, USA. The contents of this publication are solely the responsibility of the authors and do not represent the official views of the National Institutes of Health (NIH)/ National Institute on Alcohol Abuse and Alcoholism (NIAAA).
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TH and HS: conceptualized the article. HS: conducted the data analysis and wrote the article. TH.: guided the data analysis and reviewed the manuscript. TH, SS, JS RJS, SS, JS, SG, KJ, RP: reviewed and edited the manuscript. All authors have read and agreed to the published version of the manuscript.
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The study was approved by the Institutional Review Board of the University of Connecticut Health Center, the India Council for Medical Research, the Health Ministry Screening Committee, the National AIDS Control Organization and Institutional Review Boards of all collaborating agencies and hospitals.
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Ha, T., Shi, H., Singh, R.J. et al. Alcohol Use, HIV Stigma and Quality of Life Among Alcohol Consuming Men Living with HIV in India: A Mediation Analysis. AIDS Behav 27, 3272–3284 (2023). https://doi.org/10.1007/s10461-023-04047-7
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DOI: https://doi.org/10.1007/s10461-023-04047-7