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Emerging Trends in Heart Valve Engineering: Part IV. Computational Modeling and Experimental Studies

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Abstract

In this final portion of an extensive review of heart valve engineering, we focus on the computational methods and experimental studies related to heart valves. The discussion begins with a thorough review of computational modeling and the governing equations of fluid and structural interaction. We then move onto multiscale and disease specific modeling. Finally, advanced methods related to in vitro testing of the heart valves are reviewed. This section of the review series is intended to illustrate application of computational methods and experimental studies and their interrelation for studying heart valves.

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Acknowledgments

This review article was prepared after the Mathematics Guiding Bioartificial Heart Valve Design meeting held at the Ohio State University, October 28 to 31, 2013. The authors would like to acknowledge the Mathematical Biosciences Institute and its grant from National Science Foundation (DMS 0931642) that facilitated the meeting.

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Authors and Affiliations

  1. Department of Biomedical Engineering, The Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, Irvine, 2410 Engineering Hall, Irvine, CA, 92697-2730, USA

    Arash Kheradvar, Elliott M. Groves, Ahmad Falahatpisheh & S. Hamed Alavi

  2. Department of Medicine, Division of Cardiology, University of California, Irvine School of Medicine, Irvine, CA, USA

    Arash Kheradvar & Elliott M. Groves

  3. Department of Bioengineering and Mechanical Engineering, University of California, Berkeley, CA, USA

    Mohammad K. Mofrad

  4. Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA

    Robert Tranquillo

  5. Department of Mechanical Engineering, School of Biomedical Engineering, Colorado State University, Fort Collins, CO, USA

    Lakshmi P. Dasi

  6. Department of Mechanical & Industrial Engineering, University of Toronto, Toronto, ON, Canada

    Craig A. Simmons

  7. Institute of Biomaterials & Biomedical Engineering, University of Toronto, Toronto, ON, Canada

    Craig A. Simmons

  8. Department of Bioengineering, Rice University, Houston, TX, USA

    K. Jane Grande-Allen

  9. Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA

    Craig J. Goergen

  10. Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands

    Frank Baaijens

  11. Houston Methodist DeBakey Heart & Vascular Center, Houston, TX, USA

    Stephen H. Little

  12. Department of Mathematics, University of Houston, Houston, TX, USA

    Suncica Canic

  13. Department of Mathematics, Center for Interdisciplinary Applied Mathematics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

    Boyce Griffith

  14. McAllister Heart Institute, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA

    Boyce Griffith

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  1. Arash Kheradvar
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Correspondence to Arash Kheradvar.

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Associate Editor K. A. Athanasiou oversaw the review of this article.

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Kheradvar, A., Groves, E.M., Falahatpisheh, A. et al. Emerging Trends in Heart Valve Engineering: Part IV. Computational Modeling and Experimental Studies. Ann Biomed Eng 43, 2314–2333 (2015). https://doi.org/10.1007/s10439-015-1394-4

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