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Macrophages as Cell-Based Delivery Systems for Nanoshells in Photothermal Therapy

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Abstract

Site-specific delivery of nanoparticles poses a significant challenge, especially in the brain where the blood–brain barrier prevents the entry of most therapeutic compounds including nanoparticle-based anti-cancer agents. In this context, the use of macrophages as vectors for the delivery of gold–silica nanoshells to infiltrating gliomas will be reviewed in this article. Gold–silica nanoshells are readily phagocytosed by macrophages without any apparent toxic effects, and the results of in vitro studies have demonstrated the migratory potential of nanoshell-loaded macrophages in human glioma spheroids. Of particular interest is the observation that, after near-infrared exposure of spheroids containing nanoshell-loaded macrophages, sufficient heat was generated to suppress spheroid growth. Collectively, these findings demonstrate the potential of macrophages as nanoshell delivery vectors for photothermal therapy of gliomas, and they certainly provide the basis for future animal studies.

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Acknowledgments

This study was partially supported by the Health Sciences System of the Nevada System of Higher Education through the Inter-Institutional Biomedical Research Activities Fund (IBRAF). This study was also supported by the Laser Microbeam and Medical Program (LAMMP) and the Chao Cancer Center Optical Biology Shared Resource at the University of California, Irvine. Henry Hirschberg is grateful for the support received from the Norwegian Radiumhospital Research Foundation.

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Authors and Affiliations

  1. Department of Health Physics and Diagnostic Sciences, University of Nevada, Las Vegas, 4505 S. Maryland Pkwy, Box 453037, Las Vegas, NV, 89154, USA

    Steen J. Madsen & Amani R. Makkouk

  2. Department of Otolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul, Korea

    Seung-Kuk Baek

  3. Beckman Laser Institute, University of California, Irvine, CA, USA

    Tatiana Krasieva & Henry Hirschberg

Authors
  1. Steen J. Madsen
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  2. Seung-Kuk Baek
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  3. Amani R. Makkouk
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  4. Tatiana Krasieva
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  5. Henry Hirschberg
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Correspondence to Steen J. Madsen.

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Associate Editor Bahman Anvari oversaw the review of this article.

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Madsen, S.J., Baek, SK., Makkouk, A.R. et al. Macrophages as Cell-Based Delivery Systems for Nanoshells in Photothermal Therapy. Ann Biomed Eng 40, 507–515 (2012). https://doi.org/10.1007/s10439-011-0415-1

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  • DOI: https://doi.org/10.1007/s10439-011-0415-1

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