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Controlled Release in Transdermal Pressure Sensitive Adhesives using Organosilicate Nanocomposites

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Abstract

Polydimethyl siloxane (PDMS) based pressure sensitive adhesives (PSA) incorporating organo-clays at different loadings were fabricated via solution casting. Partially exfoliated nanocomposites were obtained for the hydroxyl terminated PDMS in ethyl acetate solvent as determined by X-ray diffraction and atomic force microscopy. Drug release studies showed that the initial burst release was substantially reduced and the drug release could be controlled by the addition of organo-clay. Shear strength and shear adhesion failure temperature (SAFT) measurements indicated substantial improvement in adhesive properties of the PSA nanocomposite adhesives. Shear strength showed more than 200% improvement at the lower clay loadings and the SAFT increased by about 21% due to the reinforcement provided by the nano-dispersed clay platelets. It was found that by optimizing the level of the organosilicate additive to the polymer matrix, superior control over drug release kinetics and simultaneous improvements in adhesive properties could be attained for a transdermal PSA formulation.

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Acknowledgment

The research was supported in part by a grant from the National Institutes of Health (EB006203).

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Authors and Affiliations

  1. Department of Chemical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106-7217, USA

    Sohel Shaikh, Syed Qutubuddin & Harihara Baskaran

  2. Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106-7217, USA

    Anil Birdi & Harihara Baskaran

  3. Avery Dennison Specialty Tape Division, 7100 Lindsay Dr, Mentor, OH, 44060, USA

    Eric Lakatosh

Authors
  1. Sohel Shaikh
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  2. Anil Birdi
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  3. Syed Qutubuddin
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  4. Eric Lakatosh
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  5. Harihara Baskaran
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Correspondence to Harihara Baskaran.

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Shaikh, S., Birdi, A., Qutubuddin, S. et al. Controlled Release in Transdermal Pressure Sensitive Adhesives using Organosilicate Nanocomposites. Ann Biomed Eng 35, 2130–2137 (2007). https://doi.org/10.1007/s10439-007-9369-8

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  • DOI: https://doi.org/10.1007/s10439-007-9369-8

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