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Echogenic lymph nodes in the differential diagnosis of pediatric sarcoidosis

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Abstract

We present a delayed diagnosis of sarcoidosis in an 11-year-old girl by demonstrating ultrasonographic imaging findings of granulomatous cervical and abdominal lymph node involvement. Pulmonary interstitial fibrosis in addition to multi-compartmental enlarged echogenic lymph nodes could be considered sarcoidosis. Punctate echogenic foci in the cervical lymph nodes should be considered in the differential diagnosis of sarcoidosis.

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References

  1. Ellies M, Laskawi R. Diseases of the salivary glands in infants and adolescents. Head Face Med. 2010;6:1–7.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Hoffman AL, Milman N, Byg KE. Childhood sarcoidosis in Denmark 1979–1994: incidence, clinical features and laboratory results at presentation in 48 children. Acta Paediatr. 2004;93:30–6.

    Article  Google Scholar 

  3. Banks GC, Kirse DJ, Anthony E, et al. Bilateral parotitis as the initial presentation of childhood sarcoidosis. Am J Otolaryngol. 2013;34:142–4.

    Article  PubMed  Google Scholar 

  4. Matusiewicz SP, Williamson IJ, Sime PJ, et al. Plasma lactate dehydrogenase: a marker of disease activity in cryptogenic fibrosing alveolitis and extrinsic allergic alveolitis? Eur Respir J. 1993;6:1282–6.

    CAS  Google Scholar 

  5. Li W, Holdeman K, Laurini JA, et al. Sarcoidosis mimicking recurrent lymphoma. Am J Hematol. 2012;87:711–2.

    Article  PubMed  Google Scholar 

  6. Ahmadzai H, Loke WSJ, Huang S, et al. Biomarkers in sarcoidosis: a review. Curr Biomark Find. 2014;4:93–106.

    Article  CAS  Google Scholar 

  7. Ahuja A, Ying M. Sonography of neck lymph nodes. Part II: abnormal lymph nodes. Clin Radiol. 2003;58:359–66.

    Article  CAS  PubMed  Google Scholar 

  8. Imai N, Imaizumi K, Ando M, et al. Echoic features of lymph nodes with sarcoidosis determined by endobronchial ultrasound. Intern Med. 2013;52:1473–8.

    Article  PubMed  Google Scholar 

  9. Agrawal SP, Ish P, Goel AD, et al. Diagnostic utility of endobronchial ultrasound features in differentiating malignant and benign lymph nodes. Monaldi Arch Chest Dis. 2018;88:21–5.

    Article  Google Scholar 

  10. Dhooria S, Agarwal R, Aggarwal AN, et al. Differentiating tuberculosis from sarcoidosis by sonographic characteristics of lymph nodes on endobronchial ultrasonography: a study of 165 patients. J Thorac Cardiovasc Surg. 2014;148:662–7.

    Article  PubMed  Google Scholar 

  11. Jamil LH, Kashani A, Scimeca D, et al. Can endoscopic ultrasound distinguish between mediastinal benign lymph nodes and those involved by sarcoidosis, lymphoma, or metastasis? Dig Dis Sci. 2014;59:2191–8.

    Article  PubMed  Google Scholar 

  12. Ozgul MA, Çetinkaya E, Kirkil G, et al. Lymph node characteristics of sarcoidosis with endobronchial ultrasound. Endosc Ultrasound. 2014;3:232.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Wang L, Wu W, Teng J, et al. Sonographic features of endobronchial ultrasound in differentiation of benign lymph nodes. Ultrasound Med Biol. 2016;42:2785–93.

    Article  PubMed  Google Scholar 

  14. Noe MH, Rodriguez O, Taylor L, et al. High frequency ultrasound: a novel instrument to quantify granuloma burden in cutaneous sarcoidosis. Sarcoidosis Vasc Diffus Lung Dis. 2017;34:136.

    Google Scholar 

  15. Rossi G, Cavazza A, Colby TV. Pathology of sarcoidosis. Clin Rev Allergy Immunol. 2015;49:36–44.

    Article  CAS  PubMed  Google Scholar 

  16. Israel HL, Lenchner G, Steiner RM. Late development of mediastinal calcification in sarcoidosis. Am Rev Respir Dis. 1981;124:302–5.

    CAS  PubMed  Google Scholar 

  17. Gupta D, Agarwal R, Aggarwal AN, et al. Sarcoidosis and tuberculosis: the same disease with different manifestations or similar manifestations of different disorders. Curr Opin Pulm Med. 2012;18:506–16.

    Article  PubMed  Google Scholar 

  18. Verge J, Guixa J, Alejo M, et al. Cervical cystic lymph node metastasis as first manifestation of occult papillary thyroid carcinoma: report of seven cases. Head Neck. 1999;21:370–4.

    Article  CAS  PubMed  Google Scholar 

  19. Jaskiewicz K, Rzepko R, Dubaniewicz A, et al. Pregranulomatous phase of sarcoidosis: immunohistochemical diagnosis. Acta Histochem. 2006;107:473–7.

    Article  PubMed  Google Scholar 

  20. Asano S. Granulomatous lymphadenitis. J Clin Exp Hematop. 2012;52:1–16.

    Article  PubMed  Google Scholar 

  21. Marchiori E, Zanetti G, Barreto M, et al. Atypical distribution of small nodules on high resolution CT studies: patterns and differentials. Respir Med. 2011;105:1263–7.

    Article  PubMed  Google Scholar 

  22. Flament T, Bigot A, Chaigne B, et al. Pulmonary manifestations of Sjögren’s syndrome. Eur Respir Rev. 2016;25:110–23.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Radiology Department, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey

    Zuhal Bayramoglu, Ibrahim Adaletli & Ezgi Kara

  2. Pediatric Infectious Disease Department, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey

    Manolya Acar, Selda Hancerli Torun, Ozge Kaba & Ayper Somer

  3. Pathology Department, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey

    Gulcin Yegen & Sidar Bagbudar

  4. Pediatric Rheumatology Department, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey

    Rukiye Eker Omeroglu

Authors
  1. Zuhal Bayramoglu
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  2. Ibrahim Adaletli
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  3. Ezgi Kara
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  4. Manolya Acar
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  5. Selda Hancerli Torun
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  6. Ozge Kaba
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  7. Ayper Somer
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  8. Gulcin Yegen
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  9. Sidar Bagbudar
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  10. Rukiye Eker Omeroglu
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Correspondence to Zuhal Bayramoglu.

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All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions.

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Bayramoglu, Z., Adaletli, I., Kara, E. et al. Echogenic lymph nodes in the differential diagnosis of pediatric sarcoidosis. J Med Ultrasonics 46, 277–281 (2019). https://doi.org/10.1007/s10396-019-00932-8

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  • DOI: https://doi.org/10.1007/s10396-019-00932-8

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