Abstract
Solitary neurofibroma located in the hilum of the liver is extremely rare, particularly without neurofibromatosis. We herein report a case of hilar biliary neurofibroma without signs of von Recklinghausen’s disease. A 36-year-old man was admitted to our department with progressive jaundice. The case was diagnosed as hilar cholangiocarcinoma based on preoperative imaging. The patient consequently received a Roux-en-Y hepaticojejunostomy and was confirmed with neurofibroma pathologically. This is the first reported imaging finding of hilar biliary neurofibroma using contrast-enhanced ultrasound, emphasizing the differential diagnosis of biliary tumors.
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References
Rha SE, Byun JY, Jung SE, et al. Neurogenic tumors in the abdomen: tumor types and imaging characteristics. Radiographics. 2003;23:29–43.
Meyer GW, Griffiths WJ, Welsh J, et al. Hepatobiliary involvement in von Recklinghausen’s disease. Ann Intern Med. 1982;97:722–3.
Li FY, Cheng JQ, He S, et al. Primary neurofibroma of the common bile duct as an unusual cause of obstructive jaundice: a case report. Digest Dis Sci. 2005;50:1166–8.
Ray S, Das K, Mridha AR, et al. Neurofibroma of the common bile duct: a rare cause of obstructive jaundice. Am J Surg. 2011;202:E1–3.
Bechade D, Boulanger T, Palazzo L, et al. Primary neurofibroma of the common bile duct. Gastrointest Endosc. 2010;72:895–7.
Hersh JH. Health supervision for children with neurofibromatosis. Pediatrics. 2008;121:633–42.
Solomon J, Warren K, Dombi E, et al. Automated detection and volume measurement of plexiform neurofibromas in neurofibromatosis 1 using magnetic resonance imaging. Comput Med Imaging Graph. 2004;28:257–65.
Zarchi K, Wortsman X, Jemec GB. Ultrasound as a diagnostic aid in identifying neurofibromas. Pediatr Dermatol. 2014;31:535–7.
Neurofibromatosis. Conference statement. National Institutes of Health Consensus Development Conference. Arch Neurol. 1988;45:575–8.
Choi JY, Kim MJ, Lee JM, et al. Hilar cholangiocarcinoma: role of preoperative imaging with sonography, MDCT, MRI, and direct cholangiography. Am J Roentgenol. 2008;191:1448–57.
Tirumani SH, Shanbhogue AK, Vikram R, et al. Imaging of the porta hepatis: spectrum of disease. Radiographics. 2014;34:73–92.
Barajas-Gamboa JS, Florez-Salamanca L. Solitary neurofibroma in the abdominal wall of a patient without neurofibromatosis: case report. Biomedica. 2009;29:501–5.
Jiang L, Yan LN, Cheng NS, et al. Obstructive jaundice due to primary neurofibroma of the common bile duct. Digest Liver Dis. 2011;43:85.
Xu HX, Chen LD, Xie XY, et al. Enhancement pattern of hilar cholangiocarcinoma: contrast-enhanced ultrasound versus contrast-enhanced computed tomography. Eur J Radiol. 2010;75:197–202.
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Huan-ling Guo, Li-Da Chen, Zhu Wang, Yang Huang, Jin-Ya Liu, Quan-Yuan Shan, Xiao-Yan Xie, Ming-De Lu, and Wei Wang declared that they have no financial or other relations that could lead to a conflict of interest.
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All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008. Informed consent was obtained from the patient for being included in the study. Additional informed consent was obtained from the patient for whom identifying information is included in this article.
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Guo, Hl., Chen, Ld., Wang, Z. et al. Hilar biliary neurofibroma without neurofibromatosis: case report with contrast-enhanced ultrasound findings. J Med Ultrasonics 43, 537–543 (2016). https://doi.org/10.1007/s10396-016-0732-y
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DOI: https://doi.org/10.1007/s10396-016-0732-y