Abstract
We describe a case of histologically proven hepatobiliary cystadenocarcinoma with an emphasis on the longterm clinical course. The patient was a 75-year-old man who had been diagnosed as having a simple hepatic cyst at our hospital and had been followed up by abdominal sonography (US) for about 10 years. However, the lesion subsequently showed a sudden increase in size and a marked change in US findings, i.e., from a benign hepatic cyst to a complete solid lesion. Contrast-enhanced US revealed the lesion to be filled with fine vessels. This rapid change led us to strongly suspect a hepatobiliary cystadenocarcinoma and, thus, left lateral segmentectomy was performed. The patient is doing well 6 months after the surgical treatment.
Similar content being viewed by others
References
Takayasu K, Okuda K. Malignant tumors. In: Takayasu K, Okuda K, editors. Imaging in liver diseases. Oxford: Oxford University Press; 1997. p. 104–298.
Sherloch S, Dooley J. Malignant liver tumours. In: Sherlock S, Dooley J, editors. Diseases of the liver and biliary system. London: Blackwell Scientific; 2002. p. 537–562.
Ishak KG, Willis W, Cummins SD, et al. Biliary cystadenoma and cystadenocarcinoma. Cancer 1977;38:322–338.
Woods GL. Biliary cystadenocarcinoma: case report of hepatic malignancy originating in benign cystadenoma. Cancer 1981;47:2936–2941.
Iemoto Y, Kondo Y, Nakano T, et al. Biliary cystadenocarcinoma diagnosed by liver biopsy performed under ultrasonographic guidance. Gastroenterology 1983;84:399–403.
Takayasu K, Muramatsu Y, Moriyama N, et al. Imaging diagnosis of bile duct cystadenocarcinoma. Cancer 1988;61:941–946.
Choi BI, Lim JH, Han MC, et al. Biliary cystadenoma and cystadenocarcinoma: CT and sonographic findings. AJR 1989;17:57–61.
Korokbin M, Stephans DH, Lee JKT, et al. Biliary cystadenoma and cystadenocarcinoma: CT and sonographic findings. AJR 1989;153:507–511.
Nakajima T, Sugano I, Matsuzaki O, et al. Biliary cystadenocarcinoma of the liver: a clinicopathologic histochemical evaluation of nine cases. Cancer 1992;58:2426–2434.
Lei S, Howard JM. Biliary cystadenocarcinoma arising from benign cystadenoma. Arch Surg 1992;127:1478.
Wee A, Nilsson B, Kang JY, et al. Biliary cystadenocarcinoma arising in cystadenoma. Report of a case diagnosed by fine-needle aspiration cytology. Acta Cytol 1993;37:966–970.
Wang YJ, Lee SD, Lai KH, et al. Primary biliary cystic tumors of the liver. Am J Gastroenterol 1993;88:599–603.
Devaney K, Goodman ZD, Ishak KG. Hepatobiliary cystadenoma and cystadenocarcinoma. A light microscopic and immunohistochemical study of 70 patients. Am J Surg Pathol 1994;18:1078–1091.
Matsuoka Y, Hayashi K, Yano M. Malignant transformation of biliary cystadenoma with mesenchymal stroma: documentation by CT. Clin Radiol 1997;52:318–321.
Laufler JM, Baer HV, Maurer CA, et al. Biliary cystadenocarcinoma of the liver: the need for complete resection. Eur J Cancer 1998;34:1845–1851.
Siren J, Karkkainen P, Luukkonen P, et al. A case report of biliary cystadenoma and cystadenocarcinoma. Hepatogastroenterology 1998;45:83–89.
Filippi de la Palavesa MM, Vasilescu C, Habersetzer F, et al. Biliary cystadenocarcinoma: sonographic and cytologic findings. J Clin Ultrasound 1999;27:210–212.
Sato M, Ishida H, Konno K, et al. Liver tumors in children and young patients: sonographic and color Doppler findings. Abdom Imaging 2000;25:596–602.
Peyregne V, Francois Y, Isaac S, et al. Liver cystadenocarcinoma originating in cystadenoma without mesenchymal stroma. Therapeutic strategy in case of atypical radiologic criteria. A case report. Hepatogastroenterology 2001;48:247–252.
Shrikhande S, Kleeff J, Adyanthaya K, et al. Management of hepatobiliary cystadenocarcinoma. Dis Surg 2003;20:60–63.
Hai S, Hirohashi K, Uenishi T, et al. Surgical management of cystic hepatic neoplasms. J Gastroenterol 2003;38:759–764.
Sato M, Watanabe Y, Tokui K, et al. Hepatobiliary cystadenocarcinoma connected to the hepatic duct: a case report and review of the literature. Hepatogastroenterology 2003;50:1621–1624.
Akiyoshi T, Yamaguchi K, Chijiiwa K, et al. Cystadenocarcinoma of liver without mesenchymal stroma. J Gasroenterol 2003;38:588–592.
Kubota E, Katsumi K, Iida M, et al. Biliary cystadenocarcinoma followed up as benign cystadenoma for 10 years. J Gastroenterol 2003;38:278–282.
Lempinen M, Halme L, Numminen K, et al. Spontaneous rupture of a hepatic cystadenoma and cystadenocarcinoma: report of two cases. J Hepatobiliary Pancreat Surg 2005;12:409–414.
Zhang M, Yu J, Yan S, et al. Cystadenocarcinoma of the liver: a case report. Hepatobiliary Pancreat Dis Int 2005;4:464–467.
Fujii T, Harada K, Katayanagi K, et al. Intrahepatic cholangiocarcinoma with multicystic, mucinous appearance and oncocytic change. Pathol Int 2005;55:206–209.
Vogt DP, Henderson JM, Chmielewski E. Cystadenoma and cystadenocarcinoma of the liver: a single center experience. J Am Coll Surg 2005;200:727–733.
Murakami Y, Kanchiro T, Yokoyama Y, et al. Successful complete resection of biliary cystadenocarcinoma after percutaneous transhepatic portal embolization. Surgery 2005;137:577–579.
Erdogam D, Busch OR, Rauws EA, et al. Obstructive jaundice due to hepatobiliary cystadenoma or cystadenocarcinoma. World J Gastroenterol 2006;21:5735–5760.
Okazaki M, Shimizu I, Shiraishi T, et al. Hepatobiliary cystadenocarcinoma without mesenchymal stroma showing a good prognosis. J Gastroenterol Hepatol 2006;21:1356–1358.
Koroglu M, Akham O, Akpinar E, et al. Biliary cystadenoma and cystadenocarcinoma: two rare cystic liver lesions. JBR-BTR 2006;89:261–263.
Salemo S, Florena AM, Romano I, et al. Multifocal biliary cystadenocarcinoma of the liver: CT and pathologic findings. Tumori 2006;92:358–360.
Schmidt G. Liver. In: Schmidt G, editor. Differential diagnosis in ultrasound. New York: Thieme; 2005. p. 49–100.
Tanaka S, Hamada Y, Ioka T, et al. Contrast-enhanced multiphase dynamic ultrasonography for the characterization of liver tumors. J Med Ultrasonics 2005;32:57–63.
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Kudo, Y., Kikuchi, T., Sato, Y. et al. Hepatobiliary cystadenocarcinoma with rapid growth: report of a case. J Med Ultrasonics 35, 133–138 (2008). https://doi.org/10.1007/s10396-008-0178-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10396-008-0178-y