Abstracts
Aims
To explore the epidemiological impact of depression on the occurrence of gastric cancer.
Subject and methods
A systematic review and meta-analysis was conducted and the quality of involved studies were evaluated according to the Newcastle–Ottawa scale. The association between depression and the occurrence of gastric cancer is measured by calculating the combined odds ratio (OR) and the corresponding 95% confidence interval (CI). The epidemiological effect of depression was estimated by attributable risk percentage (ARP) and population attributable risk percentage (PARP).
Results
Combined with 24 eligible studies, the risk of gastric cancer in patients with depression is 1.84 times higher than that in normal people (95%CI:1.61–2.09). The corresponding results of ARP and PARP were 45.65% and 5.86% of total meta-analysis, respectively.
Conclusion
There is a positive correlation between depression and the occurrence of gastric cancer, which may be a risk factor for gastric cancer occurrence. Our results indicated that the discovery and treatment of depression was important for the prevention of gastric cancer from an epidemiological perspective.
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Acknowledgments
The authors would like to thank all the participants in the study; it would not have been possible to carry out this work without their time and contribution.
Funding
This study was funded by Henan Medical Science and Technique Foundation (Co-sponsored by province and Ministry)SB201901115, LHGJ20190838 and Henan Medical Science and Technology Program (2018020493).
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YHZ and FJD designed the study. GH, KYW, and JJY conducted electronic and manual literature retrieval. YHZ performed statistical analysis and wrote the first draft. NM, LW, CHS, and KJW provided knowledge support for manuscript improvement. All authors made critical revisions to the manuscript and approved the final version. Each author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.
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Zhang, Y., Ma, N., Duan, F. et al. Depression and the occurrence of gastric cancer: a meta-analysis based on their relationship and epidemiological evaluation. J Public Health (Berl.) 30, 1533–1543 (2022). https://doi.org/10.1007/s10389-020-01469-8
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DOI: https://doi.org/10.1007/s10389-020-01469-8