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Health-related quality of life after esophagectomy in patients with esophageal cancer

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Abstract

Esophageal cancer is one of the malignant tumors with the poorest prognosis. Esophagectomy, which is the mainstay of curative-intent treatments, imposes excessive surgical stress on the patients, and postoperative morbidity and mortality rates after esophagectomy remain high. On the other hand, the number of survivors after esophagectomy for esophageal cancer is increasing due to recent improvements in surgical techniques and multidisciplinary treatments for this cancer. However, esophagectomy still has a great influence on the fundamental aspect of patients’ lives, that is, the health-related quality of life (HR-QOL), including their physical, emotional, and social functions in the short- and long-term postoperatively. HR-QOL is a multifactorial concept used to assess the symptoms and functional changes caused by the disease itself and treatments from the patients’ perspectives. Therefore, assessing the HR-QOL of patients with esophageal cancer after esophagectomy is becoming increasingly important. However, the status of HR-QOL changes after esophagectomy has not been satisfactorily evaluated, and there is no worldwide consensus as to how the postoperative HR-QOL can be improved. This review aimed to raise awareness of healthcare providers, such as surgeons and nurses, on the importance of HR-QOL in patients with esophageal cancer after curative-intent esophagectomy by providing multifaceted information concerning the short- and long-term HR-QOLs, including the status of changes and the determinants of HR-QOL after esophagectomy, and furthermore, essential points for improvement of HR-QOL after esophagectomy.

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Acknowledgements

The authors thank Ms. Yuri Miyazaki and Fumi Koto for their helpful assistance in manuscript preparation. We would also like to thank Editage (www.editage.com) for English language editing.

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Authors and Affiliations

  1. Department of Gastroenterological Surgery, National Hospital Organization Kyushu Cancer Center, Fukuoka, 811-1395, Japan

    Yasushi Toh, Masaru Morita, Manabu Yamamoto, Yuichiro Nakashima, Masahiko Sugiyama, Hideo Uehara, Yoshiaki Fujimoto, Yuki Shin & Keiichi Shiokawa

  2. Department of Hepato-Biliary and Pancreatic Surgery, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan

    Emi Ohnishi, Tomonari Shimagaki, Yohei Mano & Keishi Sugimachi

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  1. Yasushi Toh
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Contributions

Manuscript writing: TY. Conception and design of the study: TY. Data analysis and interpretation: TY, MM, YM, NY, SK. Literature search: YM, NY, SM, UH, FY. Review of the literature and discussion: TY, MM, YM, NY, SM, UH, FY, SY, SK, OE, ST, MY, SK.

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Correspondence to Yasushi Toh.

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All the procedures performed in this study were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. This article does not contain any studies with human or animal subjects performed by any author(s).

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Toh, Y., Morita, M., Yamamoto, M. et al. Health-related quality of life after esophagectomy in patients with esophageal cancer. Esophagus 19, 47–56 (2022). https://doi.org/10.1007/s10388-021-00874-6

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