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Inhibition of anterior capsule opacification and contraction by the elevated anterior rim of the intraocular lens optic

  • Clinical Investigation
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Abstract

Purpose

To verify the anterior capsule opacification (ACO) and contraction (ACC) of the ZCB00V intraocular lens (IOL), made of the same material as the AR40e with a high ACC rate.

Study design

Retrospective cohort study.

Methods

We evaluated 35 patients at 1 week, 1, 3 and 6 months post phacoemulsification with either a ZCB00V (n = 35) or FY-60AD (n = 34) IOL implantation. The ACC rate was calculated using retroillumination images of the anterior segment, and the ACO was measured using anterior segment photographs and image analysis software. The contact grade between the IOL and anterior capsule was estimated from the Pentacam® images.

Results

The postoperative ACC rates (mean ± standard deviation) at 3 months were 1.03%±2.54% for the ZCB00V and, and 7.12%±9.47% for the FY-60AD. The ZCB00V-implanted eyes showed a significantly lower postoperative ACC at 1 week, 3 months, and 6 months (P < 0.01). On the other hand, the FY-60AD-implanted eyes had more pronounced ACO, and a significantly larger area of opacification (62.24%±21.32% vs. 16.90%±8.34%; P = 0.0005). Pentacam® analysis revealed a space between the anterior capsule and IOL surface in the ZCB00V-implanted eyes, whereas the anterior capsule firmly adhered to the IOL surface in the FY-60AD-implanted eyes.

Conclusion

The ACC and ACO were significantly lower in eyes with ZCB00V IOLs compared to those with the FY-60AD. The anterior segment image analysis revealed that the elevated anterior rim of the ZCB00V IOL prevented adhesion between the anterior capsule and IOL optic surface, suggesting an open capsule effect.

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Acknowledgements

We would like to thank Editage (www.editage.com) for English language editing.

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Authors and Affiliations

  1. Department of Ophthalmology, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Tochigi, 321-0293, Japan

    Mayumi Nagata, Hiroyuki Matsushima, Koichiro Mukai & Tadashi Senoo

  2. Nishi Eye Hospital, Osaka, Japan

    Okihiro Nishi

Authors
  1. Mayumi Nagata
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  2. Hiroyuki Matsushima
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  3. Koichiro Mukai
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  4. Tadashi Senoo
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  5. Okihiro Nishi
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Correspondence to Mayumi Nagata.

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Conflicts of interest

M. Nagata, None; H. Matsushima, None; K. Mukai, None; T. Senoo, None; O. Nishi, None.

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Corresponding Author: Mayumi Nagata

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Nagata, M., Matsushima, H., Mukai, K. et al. Inhibition of anterior capsule opacification and contraction by the elevated anterior rim of the intraocular lens optic. Jpn J Ophthalmol 67, 693–698 (2023). https://doi.org/10.1007/s10384-023-01013-7

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  • DOI: https://doi.org/10.1007/s10384-023-01013-7

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