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Treatment of recurrent high myopic macular hole associated with retinal detachment using a human amniotic membrane

  • Clinical Investigation
  • Published:
Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To determine the efficacy of using a human amniotic membrane to close macular hole retinal detachment in highly myopic eyes.

Study design

Prospective, consecutive, nonrandomized interventional study.

Methods

We included 19 high myopic eyes from 19 patients affected by macular hole retinal detachment who had already undergone vitrectomy with internal limiting membrane peeling. The patients underwent vitrectomy with amniotic membrane transplant.

Results

Primary success was achieved after 3 months in 89.5% (17 of 19 eyes) and final macular hole closure was obtained in 94.7% (18 of 19 eyes) of the patients. The final retinal reattachment rate was 100%. The final 12-month mean BCVA improved from 20/2000 (2 logMAR) to 20/250 (1.1 logMAR). OCT-angiography revealed a high correlation between the superficial and deep capillary plexus and the final BCVA.

Conclusion

Human amniotic membrane patches can effectively repair macular hole retinal detachment in high myopic eyes in terms of anatomic results and BCVA recovery.

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References

  1. Holden BA, Fricke TR, Wilson DA, Jong M, Naidoo KS, Sankaridurg P, et al. Global prevalence of myopia and high myopia and temporal trends from 2000 through 2050. Ophthalmology. 2016;123:1036–42.

    Article  Google Scholar 

  2. Rizzo S, Giansanti F, Finocchio L, Caporossi T, Barca F, Bacherini D, et al. Vitrectomy with internal limiting membrane peeling and air tamponade for myopic foveoschisis. Retina. 2018. doi:https://doi.org/10.1097/IAE.0000000000002265.

    Article  Google Scholar 

  3. Panozzo G, Mercanti A. Optical coherence tomography findings in myopic traction maculopathy. Arch Ophthalmol. 2004;122:1455–60.

    Article  Google Scholar 

  4. Hirota K, Hirakata A. Myopic foveoschisis and macular hole retinal detachment. Surgical Retina. Retina Atlas. 2019. https://doi.org/10.1007/978-981-13-6214-9_4.

    Article  Google Scholar 

  5. Rizzo S, Tartaro R, Barca F, Caporossi T, Bacherini D, Giansanti F. Internal limiting membrane peeling versus inverted flap technique for treatment of full-thickness macular holes: a comparative study in a large series of patients. Retina. 2018;38(Suppl 1):73–8.

    Article  Google Scholar 

  6. Michalewska Z, Michalewski J, Adelman RA, Nawrocki J. Inverted internal limiting membrane flap technique for large macular holes. Ophthalmology. 2010;117:2018–25.

    Article  Google Scholar 

  7. Chen SN. Large semicircular inverted internal limiting membrane flap in the treatment of macular hole in high myopia. Graefes Arch Clin Exp Ophthalmol. 2017;255:2337–45.

    Article  CAS  Google Scholar 

  8. Kim HY, Lee JJ, Kwon HJ, Park SW, Lee JE. Long-term outcomes of macular hole retinal detachment in highly myopic eyes after surgical reattachment. Korean J Ophthalmol. 2019;33:539–46.

    Article  Google Scholar 

  9. Caporossi T, Tartaro R, Bacherini D, Pacini B, De Angelis L, Governatori L, et al. Applications of the amniotic membrane in vitreoretinal surgery. J Clin Med. 2020;9:2675. https://doi.org/10.3390/jcm9082675.

    Article  Google Scholar 

  10. Lai CC, Chen YP, Wang NK, Chuang LH, Liu L, Chen KJ, et al. Vitrectomy with internal limiting membrane repositioning and autologous blood for macular hole retinal detachment in highly myopic eyes. Ophthalmology. 2015;122:1889–98.

    Article  Google Scholar 

  11. Chen SN, Hsieh YT, Yang CM. Multiple free internal limiting membrane flap insertion in the treatment of macular hole-associated retinal detachment in high myopia. Ophthalmologica. 2018;240:143–9.

    Article  Google Scholar 

  12. Gao SS, Jia Y, Zhang M, Su JP, Liu G, Hwang TS, et al. Optical coherence tomography angiography. Investig Ophthalmol Vis Sci. 2016;57:27–36.

    Article  Google Scholar 

  13. Wilczynski T, Heinke A, Niedzielska-Krycia A, Jorg D, Michalska-Malecka K. Optical coherence tomography angiography features in patients with idiopathic full-thickness macular hole, before and after surgical treatment. Clin Interv Aging. 2019;14:505–14.

    Article  Google Scholar 

  14. Shahlaee A, Rahimy E, Hsu J, Gupta OP, Ho AC. Preoperative and postoperative features of macular holes on en face imaging and optical coherence tomography angiography. Am J Ophthalmol Case Rep. 2017;5:20–5.

    Article  Google Scholar 

  15. Wang SW, Hung KC, Tsai CY, Chen MS, Ho TC. Myopic traction maculopathy biomarkers on optical coherence tomography angiography: an overlooked mechanism of visual acuity correction in myopic eyes. Eye (Lond). 2019;33:1305–13.

    Article  CAS  Google Scholar 

  16. Holladay JT. Proper method for calculating average visual acuity. J Refract Surg. 1997;13:388–91.

    Article  CAS  Google Scholar 

  17. Kang SW, Ahn K, Ham DI. Types of macular hole closure and their clinical implications. Br J Ophthalmol. 2003;87:1015–9.

    Article  CAS  Google Scholar 

  18. Kumagai K, Furukawa M, Ogino N, Larson E. Incidence and factors related to macular hole reopening. Am J Ophthalmol. 2010;149:127–32.

    Article  Google Scholar 

  19. Sulkes DJ, Smiddy WE, Flynn HW, Feuer W. Outcomes of macular hole surgery in severely myopic eyes: a case-control study. Am J Ophthalmol. 2000;130:335–9.

    Article  CAS  Google Scholar 

  20. Ichibe M, Yoshizawa T, Murakami K, Ohta M, Oya Y, Yamamoto S, et al. Surgical management of retinal detachment associated with myopic macular hole: anatomic and functional status of the macula. Am J Ophthalmol. 2003;136:277–84.

    Article  Google Scholar 

  21. Uemoto R, Yamamoto S, Tsukahara I, Takeuchi S. Efficacy of internal limiting membrane removal for retinal detachments resulting from a myopic macular hole. Retina. 2004;24:560–6.

    Article  Google Scholar 

  22. Oie Y, Emi K, Takaoka G, Ikeda T. Effect of indocyanine green staining in peeling of internal limiting membrane for retinal detachment resulting from macular hole in myopic eyes. Ophthalmology. 2007;114:303–6.

    Article  Google Scholar 

  23. Kuriyama S, Hayashi H, Jingami Y, Kuramoto N, Akita J, Matsumoto M. Efficacy of inverted internal limiting membrane flap technique for the treatment of macular hole in high myopia. Am J Ophthalmol. 2013;156:125–31.

    Article  Google Scholar 

  24. Michalewska Z, Michalewski J, Dulczewska-Cichecka K, Nawrocki J. Inverted internal limiting membrane flap technique for surgical repair of myopic macular holes. Retina. 2014;34:664–9.

    Article  Google Scholar 

  25. Baba R, Wakabayashi Y, Umazume K, Ishikawa T, Yagi H, Muramatsu D, et al. Efficacy of the inverted internal limiting membrane flap technique with vitrectomy for retinal detachment associated with myopic macular holes. Retina. 2017;37:466–71.

    Article  Google Scholar 

  26. Mete M, Alfano A, Guerriero M, Prigione G, Sartore M, Polito A, et al. Inverted internal limiting membrane flap technique versus complete internal limiting membrane removal in myopic macular hole surgery: a comparative study. Retina. 2017;37:1923–30.

    Article  Google Scholar 

  27. Alkabes M, Mateo C. Macular buckle technique in myopic traction maculopathy: a 16-year review of the literature and a comparison with vitreous surgery. Graefes Arch Clin Exp Ophthalmol. 2018;256:863–77.

    Article  Google Scholar 

  28. Morizane Y, Shiraga F, Kimura S, Hosokawa M, Shiode Y, Kawata T, et al. Autologous transplantation of the internal limiting membrane for refractory macular holes. Am J Ophthalmol. 2014;157:861-9.e1.

    Article  Google Scholar 

  29. Dai Y, Dong F, Zhang X, Yang Z. Internal limiting membrane transplantation for unclosed and large macular holes. Graefes Arch Clin Exp Ophthalmol. 2016;254:2095–9.

    Article  CAS  Google Scholar 

  30. Grewal DS, Mahmoud TH. Autologous neurosensory retinal free flap for closure of refractory myopic macular holes. JAMA Ophthalmol. 2016;134:229–30.

    Article  Google Scholar 

  31. Wu TT, Kung YH, Chang CY, Chang SP. Surgical outcomes in eyes with extremely high myopia for macular hole without retinal detachment. Retina. 2018;38:2051–5.

    Article  Google Scholar 

  32. Rizzo S, Caporossi T, Tartaro R, Finocchio L, Franco F, Barca F, et al. A human amniotic membrane plug to promote retinal breaks repair and recurrent macular hole closure. Retina. 2019;39(Suppl 1):95–103.

    Article  Google Scholar 

  33. Caporossi T, De Angelis L, Pacini B, Tartaro R, Finocchio L, Barca F, et al. A human amniotic membrane plug to manage high myopic macular hole associated with retinal detachment. Acta Ophthalmol. 2019. doi:https://doi.org/10.1111/aos.14174.

    Article  Google Scholar 

  34. Moharram HM, Moustafa MT, Mortada HA, Abdelkader MF. Use of epimacular amniotic membrane graft in cases of recurrent retinal detachment due to failure of myopic macular hole closure. Ophthalmic Surg Lasers Imaging Retina. 2020;51:101–8.

    Article  Google Scholar 

  35. Huang YH, Tsai DC, Wang LC, Chen SJ. Comparison between cryopreserved and dehydrated human amniotic membrane graft in treating challenging cases with macular hole and macular hole retinal detachment. J Ophthalmol. 2020;2020:9157518.

    Article  Google Scholar 

  36. Abouhussein MA, Elbaha SM, Aboushousha M. Human amniotic membrane plug for macular holes coexisting with rhegmatogenous retinal detachment. Clin Ophthalmol. 2020;14:2411–6.

    Article  CAS  Google Scholar 

  37. Tartaro R, Caporossi T, Virgili G, Barca F, Giansanti F, Rizzo S. Insights on the human amniotic membrane in clinical practice with a focus on the new applications in retinal surgery. Regen Eng Transl Med. 2022;8:22–31.

    Article  Google Scholar 

  38. Rizzo S, Caporossi T, Tartaro R, Finocchio L, Pacini B, Bacherini D, et al. Human amniotic membrane plug to restore age-related macular degeneration photoreceptor damage. Ophthalmol Retina. 2020;4:996–1007.

    Article  Google Scholar 

  39. Caporossi T, Tartaro R, De Angelis L, Pacini B, Rizzo S. A human amniotic membrane plug to repair retinal detachment associated with large macular tear. Acta Ophthalmol. 2019;97:821–3.

    Article  CAS  Google Scholar 

  40. Thomas AS, Mahmoud TH. Subretinal transplantation of an autologous retinal free flap for chronic retinal detachment with proliferative vitreoretinopathy with and without macular hole. Retina. 2017. https://doi.org/10.1097/IAE.0000000000002026.

    Article  Google Scholar 

  41. Moysidis SN, Koulisis N, Adrean SD, Charles S, Chetty N, Chhablani JK, et al. Autologous retinal transplantation for primary and refractory macular holes and macular hole retinal detachments: the global consortium. Ophthalmology. 2021;128:672–85.

    Article  Google Scholar 

  42. Tam ALC, Yan P, Gan NY, Lam WC. The current surgical management of large, recurrent, or persistent macular holes. Retina. 2018;38:1263–75.

    Article  Google Scholar 

  43. Jeon HS, Byon IS, Park SW, Lee JE, Oum BS. Extramacular drainage of subretinal fluid during vitrectomy for macular hole retinal detachment in high myopia. Retina. 2014;34:1096–102.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Ophthalmology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy

    Tomaso Caporossi, Gloria Gambini, Antonio Baldascino, Umberto De Vico, Matteo Ripa, Alessandra Scampoli, Matteo Mario Carlà & Stanislao Rizzo

  2. Catholic University Sacro Cuore, Rome, Italy

    Tomaso Caporossi, Gloria Gambini, Antonio Baldascino, Umberto De Vico, Alessandra Scampoli, Matteo Mario Carlà & Stanislao Rizzo

  3. Consiglio Nazionale delle Ricerche, Istituto di Neuroscienze, Pisa, Italy

    Stanislao Rizzo

  4. Department of Neurofarba, Ophthalmology, University of Florence, Florence, Italy

    Lorenzo Governatori

  5. Ophthalmology Unit, Department of Surgical, Medical, Molecular and Critical Area Pathology, University of Pisa, Pisa, Italy

    Clara Rizzo

  6. Ophthalmology Unit, University of Verona, Verona, Italy

    Raphael Kilian

Authors
  1. Tomaso Caporossi
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  2. Lorenzo Governatori
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  3. Gloria Gambini
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  4. Antonio Baldascino
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  5. Umberto De Vico
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  7. Alessandra Scampoli
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  8. Matteo Mario Carlà
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  9. Clara Rizzo
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  10. Raphael Kilian
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  11. Stanislao Rizzo
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Corresponding author

Correspondence to Lorenzo Governatori.

Ethics declarations

Conflicts of interest

T. Caporossi, None; L. Governatori, None; G. Gambini, None; A. Baldascino, None; U. D. Vico, None; M. Ripa, None; A. Scampoli, None; M. M. Carla, None; C. Rizzo, None; R. Kilian, None; S. Rizzo, None.

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Corresponding Author: Lorenzo Governatori

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Caporossi, T., Governatori, L., Gambini, G. et al. Treatment of recurrent high myopic macular hole associated with retinal detachment using a human amniotic membrane. Jpn J Ophthalmol 66, 518–526 (2022). https://doi.org/10.1007/s10384-022-00953-w

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  • DOI: https://doi.org/10.1007/s10384-022-00953-w

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