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Comparison of ability of time-domain and spectral-domain optical coherence tomography to detect diffuse retinal nerve fiber layer atrophy

  • Clinical Investigation
  • Published:
Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

Our aim was to evaluate and compare diagnostic capabilities of time-domain (Stratus) and spectral-domain (Cirrus) optical coherence tomography (OCT) to detect diffuse retinal nerve fiber layer (RNFL) atrophy.

Methods

This study assessed 101 eyes from 101 glaucoma patients with diffuse RNFL atrophy and 101 eyes from 101 age-matched healthy individuals. Two experienced glaucoma specialists graded red-free RNFL photographs of eyes with diffuse RNFL atrophy using a four-level grading system. The area under the receiver operating characteristic curves (AUC) of normal eyes was compared with that of eyes with diffuse atrophy. Sensitivity and specificity of each OCT device were calculated on the basis of its internal normative database.

Results

The largest AUC for Stratus and Cirrus were obtained for average RNFL thicknesses (0.96 and 0.94, respectively). Comparison of the AUC with different RNFL atrophy grades revealed no significant difference between the two OCT devices. Using an internal normative database at a <5 % level, the overall sensitivity of Stratus ranged from 58.0 to 84.0 %, whereas that of Cirrus ranged from 75.0 to 87.0 %. According to the normative database, the highest Stratus sensitivity was obtained with the temporal–superior–nasal–inferior–temporal (TSNIT) thickness graph, and the highest Cirrus sensitivity with the TSNIT thickness graph and the deviation map.

Conclusions

The AUC obtained from Cirrus were comparable with those from Stratus. On the basis of their normative databases, these devices had similar diagnostic accuracy. Our results suggest that the diagnostic capabilities of the two instruments to detect diffuse RNFL atrophy are similar.

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Acknowledgments

This study was supported by grant number 04-2012-1325 from the Seoul National University Hospital Research Fund.

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Authors and Affiliations

  1. Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea

    Ko Eun Kim, Seok Hwan Kim, Jin Wook Jeoung, Ki Ho Park, Tae Woo Kim & Dong Myung Kim

  2. Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea

    Ko Eun Kim, Jin Wook Jeoung, Ki Ho Park & Dong Myung Kim

  3. Department of Ophthalmology, Seoul National University Boramae Hospital, 425 Shindaebang-dong, Dongjak-gu, Seoul, 156-707, Korea

    Seok Hwan Kim

  4. Department of Ophthalmology, Seoul National University Bundang Hospital, Seongnam, Korea

    Tae Woo Kim

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  1. Ko Eun Kim
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Corresponding author

Correspondence to Seok Hwan Kim.

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Kim, K.E., Kim, S.H., Jeoung, J.W. et al. Comparison of ability of time-domain and spectral-domain optical coherence tomography to detect diffuse retinal nerve fiber layer atrophy. Jpn J Ophthalmol 57, 529–539 (2013). https://doi.org/10.1007/s10384-013-0270-8

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  • DOI: https://doi.org/10.1007/s10384-013-0270-8

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