Zusammenfassung
GRUNDLAGEN: Hauttumore sind die häufigsten bösartigen Erkrankungen, welche bei Transplantatempfängern beobachtet werden. METHODIK: Ein Leberempfänger mit hellem Hauttyp und massiver Sonnenexposition wurde über mehrere Jahre beobachtet. ERGEBNISSE: Der Patient entwickelte innerhalb von fünf Jahren nach Transplantation eine Vielzahl von Hauttumoren. Dies inkludierte Basaliome, Spindelzellkarzinome und Melanome, welche sämtliche erfolgreich chirurgisch exzidiert wurden. Insgesamt 132 Läsionen, welche aktinischen Keratosen entsprachen, wurden in diesem Zeitraum behandelt. Letztlich wurde die Immunosuppression auf ein Minimum reduziert, und der Patient ist derzeit mit gut funktionierendem Transplantat und ohne Hinweis auf ein Rezidiv der Hepatitis C am Leben. SCHLUSSFOLGERUNGEN: Derartige Verläufe mit Entwicklung multipler Hautmalignome sind sehr selten nach Lebertransplantation. Dies zeigt jedoch, wie wichtig eine kontinuierliche dermatologische Überwachung bei diesem Patientengut ist.
Summary
BACKGROUND: Skin cancer is the most common malignant disorder following solid organ transplantation. METHODS: We followed a liver recipient, who had multiple risk factors with regard to the development of skin cancer such as fair skin and sun exposure. RESULTS: The patient developed all three common entities of skin cancer including squamous cell cancer, basal cell cancer and melanoma during a five year follow up. All lesions were successfully treated by surgical excision. A total of 132 actinic keratosis lesions were treated during this time period. The immunosuppression was minimized and the patient is currently alive with a well functioning graft and no evidence for recurrence of hepatitis C. CONCLUSIONS: The development of such an abundance of skin malignancies is extremely rare following liver transplantation. However, the case outlines the importance of continuous dermatologic surveillance in this patient population.
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Hugo Bonatti was sponsored by the Detiger fellowship.
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Nields, W., Bonatti, H., Harnois, D. et al. Squamous cell cancer, basal cell cancer and melanoma in a single liver transplant recipient. Eur Surg 39, 321–322 (2007). https://doi.org/10.1007/s10353-007-0357-x
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DOI: https://doi.org/10.1007/s10353-007-0357-x