Zusammenfassung
GRUNDLAGEN: Ovarial-Metastasierung bei Mammakarzinom kommt selten vor. METHODIK: Fallbericht. ERGEBNISSE: Wir berichten über eine 55-jährige Frau mit Brustkrebs, mit Ovarial- und Peritonealmetastasierung 2 Jahre nach Mastektomie. Sie wurde mittels zytorekutiver Chirurgie und intraperitonealer Hyperthermie-Chemoperfusion mit Cisplatin behandelt. Adjuvante systemische Chemotherapie und Hormontherapie wurden auch angewendet. Nach 40 Monaten gab es keinen Hinweis für ein Rezidiv oder Metastasen. Der Fall erscheint interessant, da ein solcher Verlauf nach Hyperthermie-Chemoperfusion noch nicht berichtet worden ist. SCHLUSSFOLGERUNGEN: Zytoreduktive Chirurgie kann eine Option in der Behandlung von Fernmetastasen bei speziellen onkologischen Situationen sein.
Summary
BACKGROUND: Ovarian breast cancer metastasis formation represents a rare condition. METHODS: Case report. RESULTS: We report on a 55-year old female patient with breast carcinoma, with formation of ovarian, omental and peritoneal metastasis 2 years after mastectomy. She was treated with cytoreductive surgery and intraperitoneal hyperthermic chemoperfusion (IPHC) with cisplatin. Adjuvant systemic chemotherapy and hormonotherapy were also applied. There was no evidence of recurrence or metastasis over the 40 months of follow-up. This case is interesting since there has been no previously published case treated with IPHC. CONCLUSIONS: Cytoreductive surgery may represent an option for treatment of distant metastasis formation in individual oncologic situations.
This is a preview of subscription content, log in via an institution to check access.
References
Elias DM, Ouellet JF (2001) Intraperitoneal chemohyperthermia: Rationale, technique, indications and results. Surg Oncol Clin N Am 10: 915–933
Brenner DE (1986) Intraperitoneal chemotherapy: A review. J Clin Oncol 4: 1135–1147
Henderson IC, Harris JR, Kinne DW, Hellman S (1989) Cancer of the breast. In: De Vita VT Jr, Hellman S, Rosenberg SA (eds) Cancer Principles and Practice of Oncology (3rd edn). Vol 1. Lippincott, Philadelphia, pp 1197–1268
Young RC, Fuks Z, Hoskins WJ (1989) Cancer of the ovary. In: De Vita VT Jr, Hellman S, Rosenberg SA, (eds) Cancer Principles and Practice of Oncology (3rd edn). Vol 1. Lippincott, Philadelphia, pp 1162–1196
Markman M (1999) Intraperitoneal chemotherapy in the management of colorectal cancer. Sem Oncol 26: 536–539
Spratt JS, Adcock RA, Muskovin M, Sherrill W, McKeown J (1980) Clinical delivery system for intraperitoneal hyperthermic chemotherapy. Cancer Res 40: 256–260
Fujimoto S, Takahashi M, Mutou T, Kobayashi K, Toyosawa T (1999) Successful intraperitoneal hyperthermic chemoperfusion for the prevention of postoperative peritoneal recurrence in patients with advanced gastric carcinoma. Cancer 85: 529–534
Yonemura Y, de Aretxabala X, Fujimura T, Fushida S, Katayama K, Bandou E, Sugiyama K, Kawamura T, Kinoshita K, Endou Y, Sasaki T (2001) Intraoperative chemohyperthermic peritoneal perfusion as an adjuvant to gastric cancer: Final results of a randomized controlled study. Hepatogastroenteroly 48: 1776–1782
Yu W, Whang I, Chung HY, Averbach A, Sugarbaker PH (2001) Indications for early postoperative intraperitoneal chemotherapy of advanced gastric cancer: Results of a prospective randomized trial. World J Surg 25: 985–990
Nomura E, Niki M, Fujii K, Shinohara H, Nishiguchi K, Sonoda T, Tanigawa N (2001) Efficacy of intraperitoneal and intravenous chemotherapy and left upper abdominal evisceration for advanced gastric cancer. Gastric Cancer 4: 75–82
Elias D, Blot F, El Otmany A, Antoun S, Lasser P, Boige V, Rougier P, Ducreux M (2001) Curative treatment of peritoneal carcinomatosis arising from colorectal cancer by complete resection and intraperitoneal chemotherapy. Cancer 92: 71–76
Sugarbaker PH (1995) Peritonectomy procedures. Ann Surg 221: 29–42
Shen P, Levine EA, Hall J, Case D, Russell G, Fleming R, McQuellon R, Geisinger KR, Loggie BW (2003) Factors predicting survival after intraperitoneal hyperthermic chemotherapy with mitomycin-C after cytoreductive surgery for patients with peritoneal carcinomatosis. Arch Surg 138: 26–33
Ferrari E, Maffeo DA, Graziano R, Gallo MS, Pignata S, De Rosa L, Montella M, Pergola M (1994) Intraperitoneal chemotherapy with carboplatin and recombinant interferon alpha in ovarian cancer. Eur J Gynaecol Oncol 15: 437–442
Braly PS, Berek JS, Blessing JA, Homesley HD, Averette H (1995) Intraperitoneal administration of cisplatin and 5-flourouracil in residual ovarian cancer: a phase II gynecologic oncology group trial. Gynecol Oncol 56: 164–168
Rothenberg ML, Liu PY, Braly PS, Wilczynski SP, Hannigan EV, Wadler S, Stuart G, Jiang C, Markman M, Alberts DS (2003) Combined Intraperitoneal and Intravenous Chemotherapy for Women with Optimally Debulked Ovarian Cancer: Results from an Intergroup Phase II Trial. J Clin Oncol 21: 1313–1319
de Bree E, Romanos J, Michalakis J, Relakis K, Georgoulias V, Melissas J, Tsiftsis DD (2003) Intraoperative hyperthermic intraperitoneal chemotherapy with docetaxelas second-line treatment for peritoneal carcinomatosis of gynecological origin. Anticancer Res 23(3C): 3019–3027
Glehen O, Mithieux F, Osinsky D, Beaujard AC, Freyer G, Guertsch P, Francois Y, Peyrat P, Panteix G, Vignal J, Gilly FN (2003) Surgery combined with peritonectomy procedures and intraperitoneal chemohyperthermia in abdominal cancers with peritoneal carcinomatosis: a phase II study. J Clin Oncol 21: 799–806
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Erdem, E., Alagöl, H. Cytoreductive surgery and intraperitoneal hyperthermic chemoperfusion in the treatment of ovarian and peritoneal metastasis from breast carcinoma – a case report. Eur Surg 38, 76–78 (2006). https://doi.org/10.1007/s10353-005-0207-7
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s10353-005-0207-7