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Fast chemical shift mapping with multiecho balanced SSFP

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Abstract

Object: A method is proposed that provides spectroscopic images with high spatial resolution and moderate spectral resolution at very short total data acquisition times.

Materials and methods: Balanced steady-state free precession (bSSFP, TrueFISP, FIESTA, b-FFE) is combined with a multiecho readout gradient and frequency-sensitive reconstruction such as Fourier reconstruction known from echo-planar spectroscopic imaging (EPSI) or matrix inversion. Balanced SSFP imaging requires short repetition times to minimize banding artefacts, thereby restricting the achievable frequency resolution.

Results: Two-dimensional (2D) high-resolution spectroscopic images were produced of three 1H resonances (water, acetone and fat) on phantoms and water/fat separation in vivo within 1–2 s. Additionally, fast 31P spectroscopic images were acquired from a phantom consisting of two resonances within 195 ms.

Conclusion: Frequency-sensitive reconstruction of multiecho bSSFP data can provide spectroscopic images with high spatial and temporal resolution while the frequency resolution is moderate at around 100 Hz. The method can also separate more than three resonances, allowing for hetero-nuclei metabolite mapping, for example 13C and 31P.

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References

  1. Brown TR, Kincaid BM, Ugurbil K (1982) NMR chemical shift imaging in three dimensions. Proc Natl Acad Sci USA 79:3523–3526

    Article  PubMed  CAS  Google Scholar 

  2. Maudsley AA, Hilal SK, Perman WH, Simon HE (1983) Spatially resolved high-resolution spectroscopy by “four-dimensional” NMR. J Magn Reson 51:147–152

    CAS  Google Scholar 

  3. Mansfield P (1984) Spatial mapping of the chemical shift in NMR. Magn Reson Med 1:370–386

    PubMed  CAS  Google Scholar 

  4. Mulkern RV, Panych LP (2001) Echo planar spectroscopic imaging. Concept Magn Res 13:213–237

    Article  CAS  Google Scholar 

  5. Heid O, Deimling M (1995) Multiecho TrueFISP imaging. Proc Int Soc Magn Reson Med 3:481

    Google Scholar 

  6. Scheffler K (2004) Fast frequency mapping with balanced SSFP: Theory and Application to Proton-Resonance Frequency Shift Thermometry. Magn Reson Med 51:1205–1211

    Article  PubMed  Google Scholar 

  7. Althaus M, Dreher W, Geppert C, Leibfritz D (2006) Fast 3D echo planar SSFP-based 1H spectroscopic imaging: demonstration on the rat brain in vivo. Magn Reson Imaging 24:549–555

    Article  PubMed  Google Scholar 

  8. Golman K, Petersson JS (2006) Metabolic imaging and other applications of hyperpolarized 13C. Acad Radiol 13:932–942

    Article  PubMed  Google Scholar 

  9. Reeder SB, Faranesh AZ, Atalar E, McVeigh ER (1999) A novel object-independent “balanced” reference scan for echo-planar imaging. J Magn Reson Imaging 9:847–852

    Article  PubMed  CAS  Google Scholar 

  10. Bieri O, Markl M, Scheffler K (2005) Analysis and compensation of eddy currents in balanced SSFP. Magn Reson Med 54:129–137

    Article  PubMed  CAS  Google Scholar 

  11. Hargreaves BA, Gold GE, Beaulieu CF, Vasanawala SS, Nishimura DG, Pauly JM (2003) Comparison of new sequences for high-resolution cartilage imaging. Magn Reson Med 49:700–709

    Article  PubMed  Google Scholar 

  12. Reeder SB, Wen Z, Yu H, Pineda AR, Gold GE, Markl M, Pelc NJ (2004) Multicoil dixon chemical species separation with an iterative least squares estimation method. Magn Reson Med 51:35–45

    Article  PubMed  CAS  Google Scholar 

  13. Wieben O, Leupold J, Mansson S, Hennig J (2005) Multi-echo balanced SSFP imaging for iterative Dixon reconstruction. Proc Int Soc Magn Reson Med 13:2386

    Google Scholar 

  14. Leupold J, Wieben O, Mansson S, Scheffler K, Petersson JS, Hennig J (2006) Fast separation of water, acetone, fat and silicone with a multiecho balanced SSFP sequence. Proc Int Soc Magn Reson Med 14:2443

    Google Scholar 

  15. Mansson S, Leupold J, Wieben O, In’t Zandt R, Magnusson P, Johansson E, Petersson JS (2006) Metabolic imaging with hyperpolarized 13C and multi-echo, single-shot RARE. Proc Int Soc Magn Reson Med 14:584

    Google Scholar 

  16. Bieri O, Scheffler K (2005) Flow compensation in balanced SSFP sequences. Magn Reson Med 54:901–907

    Article  PubMed  CAS  Google Scholar 

  17. Ebel A, Dreher W, Leibfritz D. (2000) A fast variant of 1H spectroscopic U-FLARE imaging using adjusted chemical shift phase encoding. J Magn Reson 142:241–253

    Article  PubMed  CAS  Google Scholar 

  18. Mansson S, Johansson E, Magnusson P, Chai CM, Petersson JS, Stahlberg F, Golman K (2006) 13C imaging—a new diagnostic platform. Eur Radiol 16:57–67

    Article  PubMed  Google Scholar 

  19. Golman K, Axelsson O, Johanesson H, Mansson S, Olofsson C, Petersson JS (2001) Parahydrogen-induced polarization in imaging: subsecond 13C angiography. Magn Reson Med 46:1–5

    Article  PubMed  CAS  Google Scholar 

  20. Golman K, Olsson LE, Axelsson O, Mansson S, Karlsson M, Petersson JS (2003) Molecular imaging using hyperpolarized 13C. Br J Radiol 76:118–127

    Article  Google Scholar 

  21. Bhattacharya P, Harris K, Lin AP, Mansson M, Norton VA, Perman WH, Weitekamp DP, Ross BD (2005) Ultra-fast three dimensional imaging of hyperpolarized 13C in vivo. Magn Reson Mater Phys 18:245–256

    Article  CAS  Google Scholar 

  22. Speck O, Scheffler K, Hennig J (2002) Fast 31P chemical shift imaging using SSFP methods. Magn Reson Med 48:633–639

    Article  PubMed  CAS  Google Scholar 

  23. Svensson J, Mansson S, Johansson E, Petersson JS, Olsson LE (2003) Hyperpoarized 13C MR angiography using TrueFISP. Magn Reson Med 50:256–262

    Article  PubMed  Google Scholar 

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Correspondence to Jochen Leupold.

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Leupold, J., Wieben, O., Månsson, S. et al. Fast chemical shift mapping with multiecho balanced SSFP. Magn Reson Mater Phy 19, 267–273 (2006). https://doi.org/10.1007/s10334-006-0056-9

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  • DOI: https://doi.org/10.1007/s10334-006-0056-9

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