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Dynamic interleaved 1H/31P STEAM MRS at 3 Tesla using a pneumatic force-controlled plantar flexion exercise rig

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Abstract

Objective: To develop a measurement method for interleaved acquisition of 1H and 31 STEAM localised spectra of exercising human calf muscle. Materials and Methods: A non-magnetic exercise rig with a pneumatic piston and sensors for force and pedal angle was constructed to enable plantar flexion measured in the 3 T MR scanner, which holds the dual tuned (1H ,31P) surface coil used for signal transmission and reception. Results: 31 spectra acquired in interleaved mode benefit from higher Signal to noice ratio (factor of 1.34 ±0.06 for PCr) compared to standard acquisition due to the Nuclear Overhauser effect and substantial PCr/Pi changes during exercise can be observed in 31P spectra. 1H spectral quality is equal to that in single mode experiments and allows Cr2 changes to be monitored. Conclusion: The feasibility of dynamic interleaved localised 1H and 31P spectroscopy during plantar flexion exercise has been demonstrated using a custom-built pneumatic system for muscle activation. This opens the possibility of studying the dynamics of metabolism with multi nuclear MRS in a single run.

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Authors and Affiliations

  1. MR Centre of Excellence, Medical University of Vienna, Lazarettgasse 14, A-1090, Vienna, Austria

    M. Meyerspeer, M. Krššák & E. Moser

  2. Center for Biomedical Engineering and Physics, Medical University of Vienna, A-1090, Vienna, Austria

    M. Meyerspeer & E. Moser

  3. Department of Internal Medicine III, Division of Endocrinology and Metabolism, Medical University of Vienna, A-1090, Vienna, Austria

    M. Krššák & M. Roden

  4. Division of Metabolic and Cellular Medicine, School of Clinical Science, Faculty of Medicine, University of Liverpool, Liverpool, L69 3GA, UK

    G. J. Kemp

  5. 1st Med Department, Hanusch Hospital Vienna, A-1140, Vienna, Austria

    M. Roden

Authors
  1. M. Meyerspeer
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  2. M. Krššák
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  3. G. J. Kemp
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  4. M. Roden
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  5. E. Moser
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Correspondence to E. Moser.

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Meyerspeer, M., Krššák, M., Kemp, G.J. et al. Dynamic interleaved 1H/31P STEAM MRS at 3 Tesla using a pneumatic force-controlled plantar flexion exercise rig. MAGMA 18, 257–262 (2005). https://doi.org/10.1007/s10334-005-0014-y

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  • DOI: https://doi.org/10.1007/s10334-005-0014-y

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