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Ultra-fast three dimensional imaging of hyperpolarized 13C in vivo

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Magnetic Resonance Materials in Physics, Biology and Medicine Aims and scope Submit manuscript

Abstract

Objective: PASADENA, a chemical method of enhancing nuclear spin polarization has demonstrated 13C polarizations of order unity for the nascent products of molecular addition by parahydrogen. The extreme brevity of signal enhancement obtained by hyperpolarization requires improved 13C MR in vivo imaging techniques for their optimum utility.

Materials and Methods: 13C imaging sequences, including 13C 3D FIESTA, were compiled for a GE LX 1.5 T clinical MR scanner. Two water soluble 13C imaging agents were hyperpolarized utilizing parahydrogen and an automated polarizer. 13C polarization was quantified in flow phantoms and in rats with jugular vein catheters.

Results: Fast 3D FIESTA 13C MR imaging technique acquired sequential 3D images (3.66 s/acquisition) with superior SNR. Hyperpolarized 13C solutions and vascular phantoms achieved a maximum signal of 26,624±593. In vivo 13C MR images of the cardiopulmonary circulation showed maximum 13C signal of 2,402±158. 13C images acquired within 3.66 s showed signal enhancement over 10,000 compared to equilibrium polarization.

Conclusion: 3D-FIESTA was effective for sub-second in vivo imaging of hyperpolarized 13C reagents produced in a custom-built parahydrogen polarizer. Application to 13C hyperpolarized by parahydrogen is demonstrated in vitro and in vivo

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Abbreviations

13C:

Carbon 13

DNP:

Dynamic nuclear polarization

FIESTA:

Fast imaging employing steady-state acquisition

FOV:

Field of view

HEA:

2-hydroxyethylacrylate (1−13C,2,3,3D3)

HEP:

2-hydroxyethylpropionate (1−13C,2,3,3D3)

MIP:

Maximum intensity projection

MN:

multinuclear

MRI:

Magnetic resonance imaging

MRS:

Magnetic resonance spectroscopy

NMR:

Nuclear magnetic resonance

P:

Polarization

PASADENA:

Parahydrogen and synthesis allows dramatically enhanced nuclear alignment

PHIP:

Parahydrogen induced polarization

RF:

Radio frequency

SE:

Signal enhancement

SNR:

Signal-to-noise ratio

SSFP:

Steady-state free precession

TG:

Transmit gain

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Authors and Affiliations

  1. MR Spectroscopy Unit, Huntington Medical Research Institutes, 10 Pico Street, Pasadena, CA, 91105, USA

    P. Bhattacharya, K. Harris, A. P. Lin, M. Mansson, W. H. Perman & B. D. Ross

  2. A.A. Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA, USA

    P. Bhattacharya, M. Mansson, V. A. Norton & D. P. Weitekamp

  3. Rudi Schulte Research Institute, Santa Barbara, CA, USA

    A. P. Lin, V. A. Norton & B. D. Ross

  4. Department of Radiology, St. Louis University Hospital, St. Louis, MI, USA

    W. H. Perman

Authors
  1. P. Bhattacharya
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  2. K. Harris
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  3. A. P. Lin
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  4. M. Mansson
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  5. V. A. Norton
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  6. W. H. Perman
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  7. D. P. Weitekamp
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  8. B. D. Ross
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Correspondence to B. D. Ross.

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Bhattacharya, P., Harris, K., Lin, A.P. et al. Ultra-fast three dimensional imaging of hyperpolarized 13C in vivo. MAGMA 18, 245–256 (2005). https://doi.org/10.1007/s10334-005-0007-x

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  • DOI: https://doi.org/10.1007/s10334-005-0007-x

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