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1H NMR relaxation times of skeletal muscle metabolites at 3 T

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Abstract

This study reports proton relaxation times of water and metabolites in soleus and tibialis anterior muscles of young healthy volunteers at 3 T. The results are in agreement with data reported for 1.5 and 4 T, showing a steady increase of spin-lattice relaxation times of water, creatine and lipids with B 0 and no effect of B 0 on spin–spin relaxation. Comparison between muscles revealed a longer spin–spin relaxation time of water in soleus than in tibialis anterior muscle (31±1 ms vs. 28±1 ms, p<0.05). These data can be applied to relaxation correction for the absolute quantification of skeletal muscle metabolite concentrations and further sequence optimization.

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Acknowledgments.

This study was supported by the Austrian Science Foundation (P-13213-MOB and P-15656 to M.R.; and P-15202-B02 to E.M.).

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Authors and Affiliations

  1. Division of Endocrinology and Metabolism, Department of Internal Medicine, 3University of Vienna Währinger Gürtel 18-20, 1090, Vienna, Austria

    M. Krššák & M. Roden

  2. MR-Center of Excellence, Medical University of Vienna, Vienna, Austria

    M. Krššák & M. Meyerspeer

  3. Department of Radiodiagnostics, Medical University of Vienna, Vienna, Austria

    V. Mlynárik & E. Moser

  4. Department of Medical Physics, Medical University of Vienna, Vienna, Austria

    M. Meyerspeer & E. Moser

Authors
  1. M. Krššák
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  2. M. Roden
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  3. V. Mlynárik
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  4. M. Meyerspeer
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  5. E. Moser
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Correspondence to M. Krššák.

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Krššák, M., Roden, M., Mlynárik, V. et al. 1H NMR relaxation times of skeletal muscle metabolites at 3 T. MAGMA 16, 155–159 (2004). https://doi.org/10.1007/s10334-003-0029-1

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  • DOI: https://doi.org/10.1007/s10334-003-0029-1

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