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Potential for reducing resting sympathetic nerve activity with new classes of glucose-lowering drugs in heart failure with preserved ejection fraction

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Fig. 1

Data availability

The data that support the findings of the current study are available upon request to the corresponding author.

References

  1. Anker SD, Butler J, Filippatos G, Ferreira JP, Bocchi E, Bohm M, Brunner-La Rocca HP, Choi DJ, Chopra V, Chuquiure-Valenzuela E, Giannetti N, Gomez-Mesa JE, Janssens S, Januzzi JL, Gonzalez-Juanatey JR, Merkely B, Nicholls SJ, Perrone SV, Pina IL, Ponikowski P, Senni M, Sim D, Spinar J, Squire I, Taddei S, Tsutsui H, Verma S, Vinereanu D, Zhang J, Carson P, Lam CSP, Marx N, Zeller C, Sattar N, Jamal W, Schnaidt S, Schnee JM, Brueckmann M, Pocock SJ, Zannad F, Packer M, Investigators EM-PT (2021) Empagliflozin in heart failure with a preserved ejection fraction. N Engl J Med 385:1451–1461

    Article  CAS  PubMed  Google Scholar 

  2. Barretto AC, Santos AC, Munhoz R, Rondon MU, Franco FG, Trombetta IC, Roveda F, de Matos LN, Braga AM, Middlekauff HR, Negrao CE (2009) Increased muscle sympathetic nerve activity predicts mortality in heart failure patients. Int J Cardiol 135:302–307

    Article  PubMed  Google Scholar 

  3. Belli M, Barone L, Bellia A, Sergi D, Lecis D, Prandi FR, Milite M, Galluccio C, Muscoli S, Romeo F, Barilla F (2022) Treatment of HFpEF beyond the SGLT2-is: does the addition of GLP-1 RA improve cardiometabolic risk and outcomes in diabetic patients? Int J Mol Sci 23:14598

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Bruno RM, Daghini E, Ghiadoni L, Sudano I, Rugani I, Varanini M, Passino C, Emdin M, Taddei S (2012) Effect of acute administration of vitamin C on muscle sympathetic activity, cardiac sympathovagal balance, and baroreflex sensitivity in hypertensive patients. Am J Clin Nutr 96:302–308

    Article  CAS  PubMed  Google Scholar 

  5. Diaz HS, Toledo C, Andrade DC, Marcus NJ, Del Rio R (2020) Neuroinflammation in heart failure: new insights for an old disease. J Physiol 598:33–59

    Article  CAS  PubMed  Google Scholar 

  6. Dong M, Wen S, Zhou L (2022) The relationship between the blood-brain-barrier and the central effects of glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors. Diabetes Metab Syndr Obes 15:2583–2597

    Article  PubMed  PubMed Central  Google Scholar 

  7. Fonkoue IT, Le NA, Kankam ML, DaCosta D, Jones TN, Marvar PJ, Park J (2019) Sympathoexcitation and impaired arterial baroreflex sensitivity are linked to vascular inflammation in individuals with elevated resting blood pressure. Physiol Rep 7:e14057

    Article  PubMed  PubMed Central  Google Scholar 

  8. Hamaoka T, Murai H, Hirai T, Sugimoto H, Mukai Y, Inoue O, Takashima S, Kato T, Takata S, Usui S, Sakata K, Kawashiri MA, Takamura M (2021) Different responses of muscle sympathetic nerve activity to dapagliflozin between patients with type 2 diabetes with and without heart failure. J Am Heart Assoc 10:e022637

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Heidenreich PA, Bozkurt B, Aguilar D, Allen LA, Byun JJ, Colvin MM, Deswal A, Drazner MH, Dunlay SM, Evers LR, Fang JC, Fedson SE, Fonarow GC, Hayek SS, Hernandez AF, Khazanie P, Kittleson MM, Lee CS, Link MS, Milano CA, Nnacheta LC, Sandhu AT, Stevenson LW, Vardeny O, Vest AR, Yancy CW (2022) 2022 AHA/ACC/HFSA guideline for the management of heart failure: a report of the American College of Cardiology/American Heart Association joint committee on clinical practice guidelines. J Am Coll Cardiol 79:e263–e421

    Article  PubMed  Google Scholar 

  10. Heusser K, Tank J, Diedrich A, Fischer A, Heise T, Jordan J (2023) Randomized trial comparing SGLT2 inhibition and hydrochlorothiazide on sympathetic traffic in type 2 diabetes. Kidney Int Rep 8:2254–2264

    Article  PubMed  PubMed Central  Google Scholar 

  11. Lambert GW, Schlaich MP, Eikelis N, Lambert EA (2019) Sympathetic activity in obesity: a brief review of methods and supportive data. Ann N Y Acad Sci 1454:56–67

    Article  ADS  PubMed  Google Scholar 

  12. Pauza AG, Thakkar P, Tasic T, Felippe I, Bishop P, Greenwood MP, Rysevaite-Kyguoliene K, Ast J, Broichhagen J, Hodson DJ, Salgado HC, Pauza DH, Japundzic-Zigon N, Paton JFR, Murphy D (2022) GLP1R attenuates sympathetic response to high glucose via carotid body inhibition. Circ Res 130:694–707

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Sarma S, MacNamara JP, Balmain BN, Hearon CM Jr, Wakeham DJ, Tomlinson AR, Hynan LS, Babb TG, Levine BD (2023) Challenging the hemodynamic hypothesis in heart failure with preserved ejection fraction: is exercise capacity limited by elevated pulmonary capillary wedge pressure? Circulation 147:378–387

    Article  CAS  PubMed  Google Scholar 

  14. Wen S, Nguyen T, Gong M, Yuan X, Wang C, Jin J, Zhou L (2021) An overview of similarities and differences in metabolic actions and effects of central nervous system between glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium glucose co-transporter-2 inhibitors (SGLT-2is). Diabetes Metab Syndr Obes 14:2955–2972

    Article  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

We thank all the participants for their time and effort in completing this study, and Lauren Houston and Belinda Sanchez for their laboratory assistance.

Funding

This study was supported by the National Institutes of Health (grant no: P01HL137630) and Harry S Moss Heart Trust, Bank of America, N.A., Trustee.

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Correspondence to Qi Fu.

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Washio, T., Hissen, S.L., Takeda, R. et al. Potential for reducing resting sympathetic nerve activity with new classes of glucose-lowering drugs in heart failure with preserved ejection fraction. Clin Auton Res 34, 223–226 (2024). https://doi.org/10.1007/s10286-023-01013-0

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  • DOI: https://doi.org/10.1007/s10286-023-01013-0

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