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Neurogenic lower urinary tract dysfunction predicts prognosis in patients with multiple system atrophy

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Abstract

Purpose

To evaluate whether neurogenic lower urinary tract dysfunction and urodynamic parameters predict the outcomes of patients with multiple system atrophy (MSA).

Methods

A retrospective study was performed in patients who were diagnosed with MSA and underwent urodynamic studies simultaneously from September 2014 to July 2018. The urodynamic traces were reviewed by urologists. Detrusor contractility was evaluated by the bladder contractility index (BCI) and Schäfer nomogram. Telephone follow-up was conducted in July 2019 to acquire survival data. Clinical and urodynamic parameters were analyzed for survival using Cox regression analysis.

Results

Overall, 70 MSA patients were eligible for analysis, and 61 of them underwent urodynamic study within 3 years of initial symptom onset. The parkinsonian subtype of MSA (MSA-P) had a smaller proportion of men as well as longer motor and lower urinary tract symptom durations than the cerebellar subtype (MSA-C). MSA-P also had a lower mean BCI than MSA-C (32.0 ± 27.0 versus 53.6 ± 33.4, p = 0.025). The mean MSA survival time was 5.4 [95% confidence interval (CI) 4.8–6.3] years. Cox regression analysis showed that survival from baseline was correlated only with BCI [hazard ratio (HR) 0.983, 95% CI 0.969–0.997, p = 0.020]. Overall survival was correlated with BCI (HR 0.982, 95% CI 0.966–0.999, p = 0.039) and the presence of urinary incontinence (HR 3.007, 95% CI 0.993–9.220, p = 0.052).

Conclusion

Detrusor contractility can be a prognostic marker in MSA patients. A high BCI value is a protective factor for survival from baseline and overall survival. The presence of urinary incontinence predicts shortened overall survival.

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Authors and Affiliations

  1. Department of Urology, Xuanwu Hospital, Capital Medical University, Beijing, 100045, China

    Tianying Xing, Chunsong Jia & Tongwen Ou

  2. Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100045, China

    Jinghong Ma

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  1. Tianying Xing
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  2. Jinghong Ma
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  3. Chunsong Jia
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  4. Tongwen Ou
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Correspondence to Tongwen Ou.

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The authors declare that they have no conflicts of interest.

Ethical standards

This study was approved by the Xuanwu Hospital Ethics Committee and performed in accordance with the Declaration of Helsinki.

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Xing, T., Ma, J., Jia, C. et al. Neurogenic lower urinary tract dysfunction predicts prognosis in patients with multiple system atrophy. Clin Auton Res 30, 247–254 (2020). https://doi.org/10.1007/s10286-020-00678-1

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  • DOI: https://doi.org/10.1007/s10286-020-00678-1

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