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Effet de la radiothérapie sur les cellules souches cancéreuses de cancer du sein : résistance, reprogrammation et traitements

The effect of radiotherapy on breast cancer stem cells: Resistance, reprogramming and treatments

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Oncologie

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Résumé

L’identification des cellules souches cancéreuses (CSC) cette dernière décennie a permis l’émergence de nouveaux espoirs. Néanmoins, leur caractérisation a mis en évidence une certaine résistance aux traitements anticancéreux tels que la radiothérapie. De plus, il a récemment été montré que certaines cellules non-CSC pouvaient réacquérir le phénotype de cellules souches cancéreuses sous l’effet de traitement anticancéreux, enrichissant d’autant la population résistante. Nous proposons dans cette revue de faire un tour d’horizon des différentes propriétés des CSC et tout particulièrement des mécanismes de radiorésistance, de reprogrammation et des approches thérapeutiques envisagées pour outrepasser ces résistances.

Abstract

In the past decade, the identification of cancer stem cells (CSCs) has raised new hope for the development of anticancer therapies. Nevertheless, CSC characterization highlights the relative resistance of CSCs to conventional therapies such as ionizing radiation. Moreover, it has been recently shown that some anti-cancer treatments could induce non- CSCs reprogramming into CSCs through anti-cancer treatment effect, enriching tumors with resistant cells. In this review, we will discuss CSC properties; we will especially describe the radio-resistance of CSC, reprogramming and explore the therapeutic approaches to by-pass these resistances.

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Authors and Affiliations

  1. Inserm U908, CPAC, Cell Plasticity and Cancer, Lille-I University, Sciences and Technologies, Building SN3, Office 321, F-59655, Villeneuve-d’Ascq, France

    J. Bailleul-Dubois, N. Bidan, X. Le Bourhis & C. Lagadec

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  1. J. Bailleul-Dubois
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  2. N. Bidan
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  3. X. Le Bourhis
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  4. C. Lagadec
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Correspondence to C. Lagadec.

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Bailleul-Dubois, J., Bidan, N., Le Bourhis, X. et al. Effet de la radiothérapie sur les cellules souches cancéreuses de cancer du sein : résistance, reprogrammation et traitements. Oncologie 19, 77–84 (2017). https://doi.org/10.1007/s10269-017-2699-8

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  • DOI: https://doi.org/10.1007/s10269-017-2699-8

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