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Les biomarqueurs de la maladie thromboembolique veineuse chez le patient atteint de cancer

The Biomarkers of Venous Thromboembolism in Cancer Patients

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Oncologie

Résumé

L’association entre thrombose et cancer est à ce jour clairement établie. Le risque de la maladie thromboembolique veineuse (MTEV) chez le patient atteint de cancer varie selon différents facteurs liés au patient, à la tumeur elle-même et au traitement. Ainsi, le lien étroit entre la MTEV et le type de cancer est complexe et dû à des interconnexions entre la progression tumorale, le processus inflammatoire et l’hémostase. Plusieurs biomarqueurs ont été identifiés dans la détection de thromboses chez les patients atteints de cancer. Cette revue se propose de faire une synthèse des biomarqueurs conventionnels, utilisés en routine et inclus dans des scores de risques, et de discuter des biomarqueurs émergents.

Abstract

Today, the thrombosis associated with cancer is clearly established. The risk of venous thromboembolism (VTE) in cancer is dependent on clinical parameters of cancer patients and the type of tumor. Thus, the relationship between VTE and the type of cancer is complex, caused by the tumor progression, the inflammatory state, and the hemostasis. Several biomarkers had been identified to detect VTE in cancer patients. This review summarizes usual biomarkers, assessed regularly in laboratory and included in risk assessment score, and discusses new biomarkers for prediction of VTE.

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Authors and Affiliations

  1. Aix-Marseille Université, Inserm UMR-S1076, Vascular Research Center of Marseille (VRCM), 27, boulevard Jean-Moulin, F-13005, Marseille, France

    S. Mezouar, R. Darbousset, C. Frère, L. Panicot-Dubois & C. Dubois

  2. Service d’oncologie, institut Sainte-Catherine, 250, Chemin de Baigne Pieds, F-84918, Avignon Cedex 9, France

    P. Debourdeau

  3. Service de médecine interne et pathologie vasculaire, hôpital Saint-Louis, Assistance publique–Hôpitaux de Paris, 1, avenue Claude Vellefaux, F-75010, Paris, France

    D. Farge-Bancel

  4. Laboratoire d’hématologie, centre hospitalo-universitaire Conception, 385, boulevard Baille, F-13005, Marseille, France

    F. Dignat-George

Authors
  1. S. Mezouar
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  2. R. Darbousset
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  3. C. Frère
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  4. P. Debourdeau
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  5. D. Farge-Bancel
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  6. F. Dignat-George
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  7. L. Panicot-Dubois
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  8. C. Dubois
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Corresponding author

Correspondence to C. Dubois.

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Mezouar, S., Darbousset, R., Frère, C. et al. Les biomarqueurs de la maladie thromboembolique veineuse chez le patient atteint de cancer. Oncologie 18, 17–21 (2016). https://doi.org/10.1007/s10269-015-2579-z

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  • DOI: https://doi.org/10.1007/s10269-015-2579-z

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