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Thirst intensity survey in ADPKD patients

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A Correction to this article was published on 10 July 2023

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Abstract

Introduction

With increased fluid intake and tolvaptan treatment, the growth rate of cysts can be theoretically decelerated in autosomal polycystic kidney disease. In this prospective study, it was planned to evaluate thirst sensation in these patients and the parameters affecting its intensity.

Methods

Forty-one ADPKD patients on tolvaptan and 40 ADPKD patients not on tolvaptan as the control group were evaluated for thirst distress sensation and intensity. The feeling of thirst and the discomfort caused by excessive fluid intake was assessed with Thirst Distress Scale-HF 12 questions (60/12). Thirst intensity was evaluated with a 100 mm visual scale.

Results

Of the whole group, 35.8% (29) were males, and 64.2% (52) were females. The mean age of the tolvaptan group was 39.17 ± 9.35 years and for the control group, it was 41.95 ± 12.29 years. There was a negative correlation between the thirst distress score of the patients and an increase in creatinine level after a year of tolvaptan treatment (r = − 0.335, p = 0.035). The patients not taking thiazide had higher thirst intensity scores (p = 0.004). There was no impact of tolvaptan dosage, total kidney volume, serum sodium, urinary osmolarity or eGFR on thirst distress and thirst intensity scores.

Discussion/conclusion

Only thiazide co-treatment had a positive impact on thirst distress and intensity when given tolvaptan. Thirst Distress Scale for ADPKD patients can be used to classify patients before and during tolvaptan treatment.

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Data availability

All data generated and analyzed during this study were included in this article. Further enquiries can be directed to the corresponding author.

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Authors and Affiliations

  1. Department of Nephrology, Kocaeli University Hospital, Umuttepe, Kocaeli, 41100, Turkey

    Sibel Gokcay Gocay Bek, Nuriye Yıldız, Metin Ergul, Necmi Eren, Erkan Dervisoglu & Betul Kalender

  2. Department of Nephrology, Sakarya University, Sakarya, Turkey

    Mahmud Islam

  3. Department of Internal Medicine, Kocaeli University Hospital, Kocaeli, Turkey

    Irem Sarıoglu

  4. Kocaeli Public Hospital, Kocaeli, Turkey

    Dilek Guven Taymez

  5. Department of Radiology, Kocaeli University Hospital, Kocaeli, Turkey

    Hande Uslu & Mesude Tosun

  6. Department of Biostatistics and Medical Informatics, Kocaeli University Hospital, Kocaeli, Turkey

    Sibel Balcı

  7. Department of Neurobiology, Care Sciences and Society, Karollinska Institute, Huddinge, Sweden

    Nana Waldreus

Authors
  1. Sibel Gokcay Gocay Bek
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  2. Nuriye Yıldız
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  3. Mahmud Islam
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  12. Sibel Balcı
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  13. Nana Waldreus
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Contributions

Conception: SB, NW. Design: SB, NW. Supervision: SB. Data collection: NY, ME, MT, MI, IS, DGT, NE, BK, ED. Analysis and interpretation: Sibel Bek, Sibel Balcı. Literature review: Sibel Bek, Mahmut Islam, Nana Waldreus. Writer: Sibel Bek, Mahmud Islam.

Corresponding author

Correspondence to Sibel Gokcay Gocay Bek.

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Conflict of interest

The authors have no conflict of interest to declare.

Ethical approval

The study complies with the Declaration of Helsinki. Ethics approval for the study was obtained from the Ethics Committee of Kocaeli University Hospital (GOKAEK-2021/12.03). Written informed consent was obtained from the participants who volunteered to take the survey and participate in the study.

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The original online version of this article was revised: In the original publication, the corresponding author name has been inadvertently appeared as Sibel Gokcay Gokcay Bek.

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Gocay Bek, S.G., Yıldız, N., Islam, M. et al. Thirst intensity survey in ADPKD patients. Clin Exp Nephrol 27, 819–827 (2023). https://doi.org/10.1007/s10157-023-02373-7

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  • DOI: https://doi.org/10.1007/s10157-023-02373-7

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