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Correlation between IgAC3 ratio and oxford score in IgA nephropathy

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Abstract

Background

Complement activation has an important role in the pathogenesis of IgA nephropathy.

Objective

To determine the correlation between IgAC3 ratio (IgA/C3) and total Oxford score and predictive value of IgA/C3 in IgA nephropathy.

Methods

Forty-three patients diagnosed with IgA nephropathy with > 10 glomerular + 1 arteries in biopsy were included in the study. Hematological and biochemical variables of the blood sample taken before the biopsy and total Oxford score were recorded. The study group was divided into two groups as proteinuria ≥ 1 g (PU ≥ 1) and proteinuria < 1 g (PU < 1). Statistics were carried out with SPSS 22.0 program. p < .05 considered as significant.

Results

The mean age of 43 patients was 40.4 (± 11.9) years; 51.2% of them were women. Proteinuria as 1 g or more was in 27 of 43 patients, and less than 1 g in 16 patients. The serum C3 level was lower in the group with PU ≥ 1 and showed a significant positive correlation with the IgA/C3 total Oxford score.

Conclusion

A significant correlation was found between serum IgA/C3 and total Oxford score.

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Authors and Affiliations

  1. Ankara Training and Research Hospital Nephrology Department, Ankara, Turkey

    Semahat Karahisar Şirali & Refika Büberci

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  1. Semahat Karahisar Şirali
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  2. Refika Büberci
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Correspondence to Semahat Karahisar Şirali.

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The authors have declared that no conflict of interest exists.

Ethical approval

The study complied with the ethical principles of the Declaration of Helsinki and was approved by the ethics committee of our hospital (E-19).

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Informed consent was obtained from all patients before biopsy.

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Karahisar Şirali, S., Büberci, R. Correlation between IgAC3 ratio and oxford score in IgA nephropathy. Clin Exp Nephrol 26, 982–987 (2022). https://doi.org/10.1007/s10157-022-02244-7

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  • DOI: https://doi.org/10.1007/s10157-022-02244-7

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