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Tubulointerstitial nephritis and uveitis (TINU) syndrome caused by the Chinese herb “Goreisan”

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Abstract

A 58-year-old man was admitted to our hospital complaining of fever and arthralgia. His clinical course and marked ciliary hyperemia led us to suspect tubulointestinal nephritis and uveitis (TINU) syndrome, which was confirmed ophthalmologically and by renal biopsy. Results of a drug-induced lymphocyte-stimulating test were positive for the Chinese herb “Goreisan.” This is the first case in which the use of “Goreisan” was causally related to TINU syndrome.

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References

  1. Dobrin RS, Vernier RL, Fish AL. Acute eosinophilic interstitial nephritis and renal failure with bone marrow-lymph node granulomas and anterior uveitis. A new syndrome. Am J Med. 1975;59:325–33.

    Article  CAS  PubMed  Google Scholar 

  2. Yoshioka K, Takemura T, Kanasaki M, Akano N, Maki S. Acute interstitial nephritis and uveitis syndrome: activated immune cell infiltration in the kidney. Pediatr Nephrol. 1991;5:232–4.

    Article  CAS  PubMed  Google Scholar 

  3. Mandeville JT, Levinson RD, Holland GN. The tubulointerstitial nephritis and uveitis syndrome. Surv Ophthalmol. 2001;46:195–208.

    Article  CAS  PubMed  Google Scholar 

  4. Tanaka A, Nishida R, Maeda K, Sugawara A, Kuwahara T. Chinese herb nephropathy in Japan presents adult-onset Fanconi syndrome: could different components of aristolochic acids cause a different type of Cinese herb nephropathy? Clin Nephrol. 2000;53:301–6.

    PubMed  CAS  Google Scholar 

  5. Saad N, Kalowski S, Mikus V. Primary tubulointerstitial nephritis and uveitis syndrome. Aust N Z J Ophthalmol. 1993;21:279.

    Article  CAS  PubMed  Google Scholar 

  6. Grefer J, Santer R, Ankermann T, Faul S, Nolle B, Eggert P. Tubulointerstitial nephritis and uveitis in association with Epstein-Barr virus infection. Pediatr Nephrol. 1999;13:336–9.

    Article  CAS  PubMed  Google Scholar 

  7. Pichler WJ, Tilch J. The lymphocyte transformation test in the diagnosis of drug hypersensitivity. Allergy. 2004;59:809–20.

    Article  CAS  PubMed  Google Scholar 

  8. Mantani N, Sakai S, Kogure T, Goto H, Shibahara N, Kita T, et al. Herbal medicine and false-positive results on lymphocyte transformation test. Yakugaku Zasshi. 2002;122:399–402.

    Article  CAS  PubMed  Google Scholar 

  9. Sessa A, Meroni M, Battini G, Vigano G, Brambilla PL, Paties CT. Acute renal failure due to idiopathic tublo-interstinal nephritis and uveitis: “TINU syndrome”. Case report and review of the literature. J Nephrol. 2000;13:377–80.

    PubMed  CAS  Google Scholar 

  10. Cacoub P, Deray G, Le Hoang P, Baumelou A, Beaufils H, de Groc F, et al. Idiopathic acute interstitial nephriyis associated with anterior uveitis in adults. Clin Nephrol. 1989;31:307–10.

    PubMed  CAS  Google Scholar 

  11. Salu P, Stempels N, Vanden Houte K, Verbeelen D. Acute tubulointerstitial nephritis and uveitis syndrome in the elderly. Br J Ophthalmol. 1990;74:53–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Internal Medicine, Osaka City General Hospital, 2-13-22 Miyakojima-Hondori, Miyakojima, Osaka, 534-0021, Japan

    Hisa Suzuki, Katsunobu Yoshioka, Masato Miyano, Isseki Maeda & Keiko Yamagami

  2. Department of Nephrology and Hypertension, Osaka City General Hospital, 2-13-22 Miyakojima-Hondori, Miyakojima, Osaka, 534-0021, Japan

    Takashi Morikawa, Noriyuki Okada, Yoshio Konishi & Masahito Imanishi

Authors
  1. Hisa Suzuki
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  2. Katsunobu Yoshioka
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  3. Masato Miyano
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  4. Isseki Maeda
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  5. Keiko Yamagami
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  6. Takashi Morikawa
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  7. Noriyuki Okada
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  8. Yoshio Konishi
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  9. Masahito Imanishi
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Corresponding author

Correspondence to Hisa Suzuki.

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Suzuki, H., Yoshioka, K., Miyano, M. et al. Tubulointerstitial nephritis and uveitis (TINU) syndrome caused by the Chinese herb “Goreisan”. Clin Exp Nephrol 13, 73–76 (2009). https://doi.org/10.1007/s10157-008-0069-y

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  • DOI: https://doi.org/10.1007/s10157-008-0069-y

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