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The incidence of newly diagnosed secondary cancer; sub-analysis the prospective study of the second-look procedure for transoral surgery in patients with T1 and T2 head and neck cancer

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Abstract

Background

Our prospective study of patients with early T-stage head and neck cancer indicated a high incidence of newly diagnosed secondary malignancies during the follow-up period. We aimed to determine the incidence rate and risk factors of secondary malignancies in early-stage head and neck cancer patients.

Methods

We sub-analyzed the patient data of a previous study focusing on secondary cancer incidence. The endpoints were statistical analyses of risk factors and survival and incidence rates.

Results

The incidence rate of secondary cancer was 37%, the crude incidence of second primary cancers was 10.6 per 100 person-years, and the 5 year secondary cancer-free survival rate was 63%. The hypopharynx as the primary site was an independent significant predictive factor (odds ratio 3.96, 95% confidence interval 1.07–14.6, p = 0.039).

Conclusions

Early stages of laryngeal, oropharyngeal, and hypopharyngeal cancer had a risk of secondary cancer, especially hypopharyngeal cancer. Attention to the secondary cancer has to be paid during the follow-up period after controlling the early-stage disease. These findings highlight the need for awareness of the incidence of secondary cancer in cases of early-stage primary head and neck cancer.

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Availability of data and materials

The datasets used during the present study are available from the corresponding author upon request. All data generated or analyzed during this study are included in this published article.

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Funding

No funding was received.

Author information

Authors and Affiliations

  1. Department of Otorhinolaryngology, Head and Neck Surgery, Yokohama City University, School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan

    Goshi Nishimura, Daisuke Sano, Yasuhiro Arai, Takashi Hatano, Hideaki Takahashi, Yosuke Kitani, Kentaro Takada, Takashi Wada & Nobuhiko Oridate

Authors
  1. Goshi Nishimura
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  2. Daisuke Sano
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  3. Yasuhiro Arai
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  4. Takashi Hatano
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  5. Hideaki Takahashi
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  6. Yosuke Kitani
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  7. Kentaro Takada
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  8. Takashi Wada
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  9. Nobuhiko Oridate
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Contributions

GN and NO conceived and statistical analyzed this study, and edited this manuscript. GN, NO, DS and YA designed this study. GN, TH, HT, YK, KT and TW acquired, analyzed and interpreted the date. GN, DS and YA evaluated the quality control of data and algorithms. GN prepared this manuscript and all authors reviewed and approved the final version of the manuscript.

Corresponding author

Correspondence to Goshi Nishimura.

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Competing interests

The authors declare no conflicts of interest.

Ethics approval and consent to participate

Ethical approval for the study was obtained from the Yokohama City University Institutional Review Board (#B131107003). Written informed consent was obtained from the study participants to publish of their data.

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Nishimura, G., Sano, D., Arai, Y. et al. The incidence of newly diagnosed secondary cancer; sub-analysis the prospective study of the second-look procedure for transoral surgery in patients with T1 and T2 head and neck cancer. Int J Clin Oncol 26, 59–65 (2021). https://doi.org/10.1007/s10147-020-01779-7

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  • DOI: https://doi.org/10.1007/s10147-020-01779-7

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