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Characteristics of neoplastic cardiac tamponade and prognosis after pericardiocentesis: a single-center study of 113 consecutive cancer patients

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Abstract

Background

Neoplastic cardiac tamponade (NCT) is a life-threatening complication of cancer. The interval between cancer diagnosis and NCT onset and the prognosis after pericardiocentesis may differ according to cancer type.

Methods and results

We performed a retrospective study of 113 patients (54 % male) with NCT who underwent pericardiocentesis at Niigata Cancer Center Hospital between 1992 and 2013. Mean age at NCT was 61.2 years (range 15.9–94.8 years). The most common underlying cancers were lung cancer (59.2 %), breast cancer (21.2 %), lymphoma/leukemia (5.3 %), and gastric/esophageal cancer (5.3 %). The median time from cancer diagnosis to NCT onset was 9.0, 60.4, 5.6, and 8.0 months for lung cancer, breast cancer, lymphoma/leukemia, and gastric/esophageal cancer, respectively. Kaplan–Meier survival estimates were worse for breast cancer patients with NCT than for matched breast cancer patients without NCT (P < 0.0001). Median survival time after pericardiocentesis was 2.9, 4.2, 2.3, and 0.6 months for lung cancer, breast cancer, lymphoma/leukemia, and gastric/esophageal cancer, respectively; one-year survival after pericardiocentesis was 6.0, 16.7, 33.3, and 0 %, respectively.

Conclusions

The interval between cancer diagnosis and NCT onset, the impact of NCT on prognosis, and the prognosis after pericardiocentesis differed according to cancer type. Healthcare practitioners caring for patients with NCT should recognize the differences between cancer types and customize their care accordingly.

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References

  1. Klatt EC, Heitz DR (1990) Cardiac metastases. Cancer 65:1456–1459

    Article  CAS  PubMed  Google Scholar 

  2. Lestuzzi C (2010) Neoplastic pericardial disease: old and current strategies for diagnosis and management. World J Cardiol 2:270–279

    Article  PubMed Central  PubMed  Google Scholar 

  3. Vaitkus PT, Herrmann HC, LeWinter MM (1994) Treatment of malignant pericardial effusion. JAMA 272:59–64

    Article  CAS  PubMed  Google Scholar 

  4. De Lima L (2007) International Association for Hospice and Palliative Care list of essential medicines for palliative care. Ann Oncol 18:395–399

    Article  PubMed  Google Scholar 

  5. Ikematsu Y, Kloos JA (2012) Patients’ descriptions of dysphoria associated with cardiac tamponade. Heart Lung 41:264–270

    Article  PubMed  Google Scholar 

  6. Maisch B, Seferović PM, Ristić AD, Erbel R, Rienmüller R, Adler Y et al (2004) Guidelines on the diagnosis and management of pericardial diseases executive summary; the task force on the diagnosis and management of pericardial diseases of the European society of cardiology. Eur Heart J 25:587–610

    Article  PubMed  Google Scholar 

  7. Singh S, Wann LS, Klopfenstein HS, Hartz A, Brooks HL (1986) Usefulness of right ventricular diastolic collapse in diagnosing cardiac tamponade and comparison to pulsus paradoxus. Am J Cardiol 57:652–656

    Article  CAS  PubMed  Google Scholar 

  8. Kunitoh H, Tamura T, Shibata T, Imai M, Nishiwaki Y, Nishio M et al (2009) A randomised trial of intrapericardial bleomycin for malignant pericardial effusion with lung cancer (JCOG9811). Br J Cancer 100:464–469

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  9. Cancer Registry in Japan. http://www.jacr.info/publicication/document/CRIJ_eng.pdf. Accessed 1 Feb 2015

  10. Smith TJ, Temin S, Alesi ER, Abernethy AP, Balboni TA, Basch EM et al (2012) American Society of Clinical Oncology provisional clinical opinion: the integration of palliative care into standard oncology care. J Clin Oncol 30:880–887

    Article  PubMed  Google Scholar 

  11. Zhang B (2012) Nilsson ME, Prigerson HG: factors important to patients’ quality of life at the end of life. Arch Intern Med 172:1133–1142

    PubMed Central  PubMed  Google Scholar 

  12. Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW et al (2004) Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 350:2129–2139

    Article  CAS  PubMed  Google Scholar 

  13. Paez JG, Janne PA, Lee JC, Tracy S, Greulich H, Gabriel S et al (2004) EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 304:1497–1500

    Article  CAS  PubMed  Google Scholar 

  14. Dawood S, Broglio K, Gonzalez-Angulo AM, Buzdar AU, Hortobagyi GN, Giordano SH (2008) Trends in survival over the past two decades among white and black patients with newly diagnosed stage IV breast cancer. J Clin Oncol 26:4891–4898. doi:10.1200/JCO.2007.14.1168

    Article  PubMed Central  PubMed  Google Scholar 

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Acknowledgments

The authors report no financial or material support for this manuscript and no affiliation or financial involvement with any organization or entity with a financial interest in the topic.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Cardiology, Niigata Cancer Center Hospital, Chu-o-ku Kawagishicho 2-15-3, Niigata, 951-8560, Japan

    Tsugumi Takayama & Yuji Okura

  2. Department of Internal Medicine, Kamo Hospital, Niigata, Japan

    Yoshinobu Okada

  3. Department of Pathology, Niigata Cancer Center Hospital, Niigata, Japan

    Keiichi Honma

  4. Department of Digestive Surgery, Niigata Cancer Center Hospital, Niigata, Japan

    Atsushi Nashimoto

  5. Department of Breast Surgery, Niigata Cancer Center Hospital, Niigata, Japan

    Nobuaki Sato

  6. Department of Respiratory Medicine, Niigata Cancer Center Hospital, Niigata, Japan

    Akira Yokoyama

  7. Department of Cardiovascular Biology and Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan

    Tohru Minamino

Authors
  1. Tsugumi Takayama
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  2. Yuji Okura
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  3. Yoshinobu Okada
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  4. Keiichi Honma
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  5. Atsushi Nashimoto
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  6. Nobuaki Sato
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  7. Akira Yokoyama
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  8. Tohru Minamino
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Corresponding author

Correspondence to Yuji Okura.

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Takayama, T., Okura, Y., Okada, Y. et al. Characteristics of neoplastic cardiac tamponade and prognosis after pericardiocentesis: a single-center study of 113 consecutive cancer patients . Int J Clin Oncol 20, 872–877 (2015). https://doi.org/10.1007/s10147-015-0794-7

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  • DOI: https://doi.org/10.1007/s10147-015-0794-7

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