Abstract
Background
This study was conducted to determine the timing and characteristics of radiation pneumonitis (RP) associated with stereotactic body radiotherapy (SBRT) for stage I lung cancer.
Methods
Two hundred thirty-one patients treated with SBRT using 52 Gy in 4 fractions were identified. Control rate, RP incidence rate, and predictive factors and timing of RP were evaluated retrospectively.
Results
The 3-year overall survival and local control rates were 80.7 and 92.0 %, respectively. The grade ≥2 RP rate was 13.0 %; no grade 4–5 RP occurred. The most statistically significant predictive factor of grade ≥2 RP was V10. The median intervals to first graphical appearance were 4.2 and 2.5 months for grade 1 and grade 2–3 RP, respectively. Median intervals to maximum radiological density change were 6.0 and 4.6 months for grade 1 and grade 2–3 RP, respectively. A significantly different interval to first graphical appearance between grade 1 and grade 2–3 RP was observed; no significantly different interval to maximum radiological density change was noted.
Conclusions
The first graphical appearance of grade ≥2 RP was earlier than that of grade 1 RP, although the timing of maximum radiological density change was not significantly different.
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The authors declare that they have no competing interests.
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Kanemoto, A., Matsumoto, Y. & Sugita, T. Timing and characteristics of radiation pneumonitis after stereotactic body radiotherapy for peripherally located stage I lung cancer. Int J Clin Oncol 20, 680–685 (2015). https://doi.org/10.1007/s10147-014-0766-3
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DOI: https://doi.org/10.1007/s10147-014-0766-3