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Glasgow Prognostic Score as a useful prognostic factor after hepatectomy for hepatocellular carcinoma

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Abstract

Background

Several previous studies have revealed that the Glasgow Prognostic Score (GPS) is a clinically useful scoring system to predict the prognosis of patients with various kinds of advanced cancers. However, there have been few reports on the relationship between the GPS and prognosis after hepatectomy for hepatocellular carcinoma (HCC). Therefore, we performed an analysis of the relationship between the GPS and prognosis after hepatectomy for HCC.

Methods

Between January 2005 and December 2009, 352 HCC patients underwent hepatectomy at Kumamoto University Hospital. Nineteen clinicopathologic factors were analyzed, using univariate and multivariate analyses.

Results

Univariate analysis showed that significant risk factors for poor survival included serum albumin level (<3.5 g/dL), tumor size (>35 mm), presence of ascites, portal vein invasion, operation time (>400 min), blood loss (>360 mL), requirement for blood transfusion, and GPS. Multivariate analysis revealed that tumor size [hazard ratio (HR) 3.355; p = 0.003], operation time (HR 2.634; p = 0.006), portal vein invasion (HR 2.419; p = 0.009), and GPS (HR 3.796; p < 0.001) were independent factors for poor prognosis.

Conclusion

The GPS was demonstrated to be a statistically significant prognostic factor after hepatectomy for HCC.

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Abbreviations

GPS:

Glasgow Prognostic Score

HCC:

Hepatocellular carcinoma

Vp:

Portal vein invasion

Vv:

Hepatic vein invasion

HR:

Hazard ratio

CRP:

C-reactive protein

T-Bil:

Total bilirubin

Alb:

Albumin

PT:

Prothrombin

ICG R15:

Indocyanine green retention rate at 15 min

HBs-Ag:

Hepatitis B surface antigen

HCV-Ab:

Hepatitis C virus antibody

IL-6:

Interleukin-6

hGPS:

Hepatic Glasgow Prognostic Score

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Conflict of interest

The authors declare that they have no conflict interest.

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Authors and Affiliations

  1. Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan

    Kei Horino, Toru Beppu, Hideyuki Kuroki, Kosuke Mima, Hirohisa Okabe, Osamu Nakahara, Yoshiaki Ikuta, Akira Chikamoto, Takatoshi Ishiko, Hiroshi Takamori & Hideo Baba

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  1. Kei Horino
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  2. Toru Beppu
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  3. Hideyuki Kuroki
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  4. Kosuke Mima
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  5. Hirohisa Okabe
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  6. Osamu Nakahara
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  7. Yoshiaki Ikuta
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  8. Akira Chikamoto
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  9. Takatoshi Ishiko
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  10. Hiroshi Takamori
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  11. Hideo Baba
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Corresponding author

Correspondence to Kei Horino.

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Horino, K., Beppu, T., Kuroki, H. et al. Glasgow Prognostic Score as a useful prognostic factor after hepatectomy for hepatocellular carcinoma. Int J Clin Oncol 18, 829–838 (2013). https://doi.org/10.1007/s10147-012-0451-3

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  • DOI: https://doi.org/10.1007/s10147-012-0451-3

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