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WHO grade I meningiomas: classification-tree for prognostic factors of survival

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Abstract

World Health Organization (WHO) grade I meningiomas are intracranial extracerebral tumors, in which microsurgery as a stand-alone therapy provides high rates of disease control and low recurrence rates. Our aim was to identify prognostic factors of overall survival and time-to-retreat (OS; TTR) in a cohort of patients with surgically managed WHO grade I meningioma. Patients with WHO grade I meningiomas from a retrospectively (1990 to 2002) and prospectively managed (2003 to 2010) databank of Oslo University Hospital, Norway, were included. The mean follow-up was 9.2 ± 5.7 years, with a total of 11,414 patient-years. One thousand three hundred fifty-five patients were included. The mean age was 58 ± 13.2, mean Karnofsky Performance Status (KPS) 92.6 ± 26.1 and female-to-male ratio 2.5:1. The 1-year, 5-year, 10-year, 15-year, and 20-year probabilities were 0.98, 0.91, 0.87, 0.84, and 0.8 for TTR. Patient age (OR 0.92 [0.91, 0.94]), male sex (OR 0.59 [0.45, 0.76]), preoperative KPS ≥ 70 (OR 2.22 [1.59, 3.13]), skull base location (OR 0.77 [0.60, 1]), and the occurrence of a postoperative hematoma (OR 0.44 [0.26, 0.76]) were identified as independent prognostic factors of OS. Patient age (OR 1.02 [1.01, 1.03]) and skull base location (OR 0.30 [0.21, 0.45]) were independent predictors of decreased PFS. Using a recursive partitioning analysis, we suggest a classification tree for the prediction of 5-year PFS based on patient and tumor characteristics. The findings from this cohort of meningioma WHO I patients helps to identify patients at risk of recurrence and tailor the therapeutic management.

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Acknowledgments

The authors would like to thank Bernt Filip Hasseleid MD, Andreas Mathisen MD, Andreas Hessen Schei MD, and Kristina M. Ødegaard MD for their valuable contributions in collecting data for this manuscript and the neurosurgeons of Rikshospitalet and Ullevaal for their dedicated patient care.

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Authors and Affiliations

  1. Department of Clinical Neurosciences, Division of Neurosurgery, Geneva University Hospitals, Geneva, Switzerland

    Jean-Michel Lemée, Holger Joswig, Marco Vincenzo Corniola, Karl Schaller & Torstein R. Meling

  2. Service de Neurochirurgie, Hôpitaux Universitaires de Genève, Rue Gabriel-Perret-Gentil 5, 1205, Genève, Switzerland

    Jean-Michel Lemée

  3. Faculty of Medicine, University of Oslo, Oslo, Norway

    Michele Da Broi, Eirik Helseth & Torstein R. Meling

  4. Section of Neuropathology, Rigshospitalet, Copenhagen, Denmark

    David Scheie

  5. Faculty of Medicine, University of Geneva, Geneva, Switzerland

    Karl Schaller & Torstein R. Meling

  6. Department of Neurosurgery, Oslo University Hospital, Oslo, Norway

    Eirik Helseth & Torstein R. Meling

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  1. Jean-Michel Lemée
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Contributions

Data collection: TRM, EH, DS.

Statistical analysis: JML.

Manuscript drafting: JML, HJ, MDB, MVC, TRM.

Critical revision: all authors.

Manuscript approval: all authors.

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Correspondence to Jean-Michel Lemée.

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The study was regulated by the Personal Data Act/Personal Health Data Filing System Act and approved by the Data Protection Official at OUH (2017/5204).

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Lemée, JM., Joswig, H., Da Broi, M. et al. WHO grade I meningiomas: classification-tree for prognostic factors of survival. Neurosurg Rev 43, 749–758 (2020). https://doi.org/10.1007/s10143-019-01117-0

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