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Integrated gene networks in breast cancer development

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An Erratum to this article was published on 12 October 2010

Abstract

Breast cancer is a complex and heterogenous disease. Classical molecular medical approaches cannot fully understand and comprehend its pathogenesis. In this review, the development of new biological markers for the early detection and creation of guided and specific therapy of breast cancer are discussed in light of the rapid advances in the “omics”. Results of cancer research in combination with large-scale methods that examine the expression status of genes and proteins have identified a large number of new biomarkers as well as confirmed the human growth hormone as an important player in the pathogenesis of this disease through its autocrine regulation where it influences the activation of Pax5 and HOXA1 gene networks.

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Acknowledgments

We greatly appreciate the financial help of the Foundation of Croatian Academy of Sciences and Arts. This manuscript was also supported by the project of Ministry of Science Education and Sports 098-0982464-2393.

This work has been approved by an ethical committee of Clinical hospital “Sisters of Mercy” and all subjects gave informed consent.

Conflict of interest

The authors declare that they have no competing interests.

Author information

Authors and Affiliations

  1. Department of Biotechnology, University of Rijeka, Trg brace Mazuranica 10, 51000, Rijeka, Croatia

    Ivana Ratkaj, Kresimir Pavelic & Sandra Kraljevic Pavelic

  2. Department of Radiology, Clinical hospital “Sisters of mercy”, Vinogradska cesta 29, 10000, Zagreb, Croatia

    Emil Stajduhar

  3. Laboratory for Systems Biomedicine, Division of Molecular Medicine, Ruder Boskovic Institute, Bijenicka cesta 54, 10000, Zagreb, Croatia

    Srdan Vucinic

  4. Croatian Academy of Sciences and Arts, Zrinski trg 11, 10000, Zagreb, Croatia

    Sime Spaventi

  5. Department of Internal Medicine, Clinical hospital “Sisters of mercy”, Vinogradska cesta 29, 10000, Zagreb, Croatia

    Hrvojka Bosnjak

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  1. Ivana Ratkaj
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Correspondence to Ivana Ratkaj.

Additional information

An erratum to this article can be found at http://dx.doi.org/10.1007/s10142-010-0194-z

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Supplementary material

The immunohystochemical results showing the presence of hGH and RGH in epithelial and stromal compound of ductal invasive carcinoma and breast fibroadenoma. 0 absent, 1 weak reaction, 2 moderate reaction, 3 strong reaction (DOC 71 kb)

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Ratkaj, I., Stajduhar, E., Vucinic, S. et al. Integrated gene networks in breast cancer development. Funct Integr Genomics 10, 11–19 (2010). https://doi.org/10.1007/s10142-010-0159-2

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  • DOI: https://doi.org/10.1007/s10142-010-0159-2

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