Abstract.
Background: Our previous studies have demonstrated the significant role of the generative cells of intestinal metaplasia (IM) expressing brain (fetal)-type glycogen phosphorylase (BGP) (BGP-IM) as a premalignant lesion of intestinal-type adenocarcinoma. The aims of the present study were to investigate the incidence of BGP-IM in gastric biopsy specimens and to establish BGP-IM as a predictor of the coexistence of accessory carcinoma and/or metachronous cancers before and after local treatment for early gastric carcinoma.
Methods: We studied the incidence of BGP-IM in eight endoscopic biopsy specimens of methylene blue-positive mucosa of the stomach obtained from patients with multiple gastric carcinomas (n = 14), a single carcinoma (n = 25), and atrophic gastritis (n = 20).
Results: BGP positivity was 93.3% in the multiple carcinomas and 80.0% in the single carcinomas. The incidences of BGP-IM (mean percentage ± SD) in the stomachs with multiple carcinomas, single carcinoma, and atrophic gastritis were 83.2% ± 22.8%, 36.5% ± 41.3%, and 7.1% ± 18.0%, respectively. The incidence was significantly higher in the stomachs with multiple carcinomas than in those with a single carcinoma or those with atrophic gastritis (P < 0.001).
Conclusion: It is suggested that the frequent appearance of BGP-IM reflects the high potential of carcinogenesis of intestinal-type gastric cancer, and that the involvement of BGP-IM in more than 50% of the eight biopsies may be a predictor of the coexistence of accessory and/or metachronous carcinoma before and after local treatment for early gastric carcinoma.
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Received: January 10, 2002 / Accepted: March 26, 2002
Acknowledgment This work was supported by Grants-in-Aid (nos.11671254 and 12877194) for Scientific Research from the Ministry of Education, Japan.
Offprint requests to: M. Ogawa
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Shimada, S., Shiomori, K., Honmyo, U. et al. BGP expression in gastric biopsies may predict the development of new lesions after local treatment for early gastric cancer. Gastric Cancer 5, 0130–0136 (2002). https://doi.org/10.1007/s101200200023
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DOI: https://doi.org/10.1007/s101200200023