Skip to main content

Advertisement

SpringerLink
Log in

Cisplatin-loaded poly(L-glutamic acid)-g-methoxy poly(ethylene glycol) nanoparticles as a potential chemotherapeutic agent against osteosarcoma

  • Papers
  • Published:
Chinese Journal of Polymer Science Aims and scope Submit manuscript

Abstract

Herein, cisplatin-loaded poly(L-glutamic acid)-g-methoxy poly(ethylene glycol) nanoparticles were evaluated as a potential chemotherapeutic agent against osteosarcoma by using alone or with an iRGD (internalizing RGD, CRGDKDPDC). The release rate of platinum from the cisplatin-loaded nanoparticles CDDP/PLG160-g-mPEG2K (CDDP-NPs) accelerated with the increase of the acidity of the environment. In vitro test demonstrated that CDDP-NPs could inhibit the proliferation of MNNG/Hos osteosarcoma cells with IC50 (72 h) of 12.2 μg·mL−1. In vivo test for MNNG/Hos osteosarcoma tumor bearing mice exhibited that CDDP-NPs had comparable or slightly higher efficacy but significantly lower side effects in comparison with free CDDP. The coadministration of iRGD could further enhance the anticancer efficacy of CDDP-NPs against MNNG/Hos osteosarcoma without bringing obvious side effects. Therefore, CDDP-NPs using alone or with iRGD have great potential for the treatment of osteosarcoma.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Kager, L., Zoubek, A., Pötschger, U., Kastner, U., Flege, S., Kempf-Bielack, B., Branscheid, D., Kotz, R., Salzer-Kuntschik, M., Winkelmann, W., Jundt, G., Kabisch, H., Reichardt, P., Jürgens, H., Gadner, H. and Bielack, S.S., J. Clin. Oncol., 2003, 21(10): 2011

    Article  Google Scholar 

  2. Link, M.P., Goorin, A.M., Miser, A.W., Green, A.A., Pratt, C.B., Belasco, J.B., Pritchard, J., Malpas, J.S., Baker, A.R., Kirkpatrick, J.A., Ayala, A.G., Shuster, J.J., Abelson, H.T., Simone, J.V. and Vietti, T.J., N. Engl. J. Med., 1986, 314(25): 1600

    Article  CAS  Google Scholar 

  3. Bielack, S.S., Kempf-Bielack, B., Delling, G., Exner, G.U., Flege, S., Helmke, K., Kotz, R., Salzer-Kuntschik, M., Werner, M., Winkelmann, W., Zoubek, A., Jürgens, H. and Winkler, K., J. Clin. Oncol., 2002, 20(3): 776

    Article  Google Scholar 

  4. Zhang, C., Yao, C., Li, H., Wang, G. and He, X., Int. J. Molecul. Sci., 2014, 15(4): 6544

    Article  CAS  Google Scholar 

  5. Longhi, A., Fabbri, N., Donati, D., Capanna, R., Briccoli, A., Biagini, R., Bernini, G., Ferrari, S., Versari, M. and Bacci, G., J. Chemother., 2001, 13(3): 324

    Article  CAS  Google Scholar 

  6. Hughes, D.P., Expert Opinion on Drug Delivery, 2009, 6(12): 1311

    Article  CAS  Google Scholar 

  7. Longhi, A., Errani, C., De Paolis, M., Mercuri, M. and Bacci, G., Cancer Treat. Rev., 2006, 32(6): 423

    Article  Google Scholar 

  8. Wang, D. and Lippard, S.J., Nat. Rev. Drug Discov., 2005, 4(4): 307

    Article  CAS  Google Scholar 

  9. Stewart, D.J., Dulberg, C.S., Mikhael, N.Z., Redmond, M.D., Montpetit, V.A.J. and Goel, R., Cancer Chemother. Pharmacol., 1997, 40(4): 293

    Article  CAS  Google Scholar 

  10. Li, Y., Lim, S. and Ooi, C., Pharm. Res., 2012, 29(3): 756

    Article  CAS  Google Scholar 

  11. van Leeuwen, B.L., Kamps, W.A., Jansen, H.W.B. and Hoekstra, H.J., Cancer Treat. Rev., 2000, 26(5): 363

    Article  Google Scholar 

  12. Baba, M., Matsumoto, Y., Kashio, A., Cabral, H., Nishiyama, N., Kataoka, K. and Yamasoba, T., J. Control. Release, 2012, 157(1): 112

    Article  CAS  Google Scholar 

  13. Plummer, R., Wilson, R., Calvert, H., Boddy, A., Griffin, M., Sludden, J., Tilby, M., Eatock, M., Pearson, D. and Ottley, C., Br. J. Cancer, 2011, 104(4): 593

    Article  CAS  Google Scholar 

  14. Mi, Y., Zhao, J. and Feng, S.S., Int. J. Pharm., 2012, 438(1–2): 98

    Article  CAS  Google Scholar 

  15. Zhang, Y., Wang, X., Guo, M., Yan, H., Wang, C. and Liu, K., Chinese J. Polym. Sci., 2014, 32(10): 1329

    Article  CAS  Google Scholar 

  16. Mei, L., Fu, L., Shi, K., Zhang, Q., Liu, Y., Tang, J., Gao, H., Zhang, Z. and He, Q., Int. J. Pharm., 2014, 468(1–2): 26

    Article  CAS  Google Scholar 

  17. Li, C., Li, Y., Gao, Y., Wei, N., Zhao, X., Wang, C., Li, Y., Xiu, X. and Cui, J., Int. J. Pharm., 2014, 468(1–2): 15

    Article  CAS  Google Scholar 

  18. Buckway, B., Wang, Y., Ray, A. and Ghandehari, H., Int. J. Pharm., 2013, 456(1): 202

    Article  CAS  Google Scholar 

  19. Maeda, H., Wu, J., Sawa, T., Matsumura, Y. and Hori, K., J. Control. Release, 2000, 65(1–2): 271

    Article  CAS  Google Scholar 

  20. Li, M., Tang, Z., Lv, S., Song, W., Hong, H., Jing, X., Zhang, Y. and Chen, X., Biomaterials, 2014, 35(12): 3851

    Article  CAS  Google Scholar 

  21. Nishiyama, N., Okazaki, S., Cabral, H., Miyamoto, M., Kato, Y., Sugiyama, Y., Nishio, K., Matsumura, Y. and Kataoka, K., Cancer Res., 2003, 63(24): 8977

    CAS  Google Scholar 

  22. Song, W., Li, M., Tang, Z., Li, Q., Yang, Y., Liu, H., Duan, T., Hong, H. and Chen, X., Macromol. Biosci., 2012, 12(11): 1514

    Article  CAS  Google Scholar 

  23. Song, W., Tang, Z., Li, M., Lv, S., Sun, H., Deng, M., Liu, H. and Chen, X., Acta Biomater., 2014, 10(3): 1392

    Article  CAS  Google Scholar 

  24. Song, W., Tang, Z., Zhang, D., Zhang, Y., Yu, H., Li, M., Lv, S., Sun, H., Deng, M. and Chen, X., Biomaterials, 2014, 35(9): 3005

    Article  CAS  Google Scholar 

  25. Song, W.T., Li, M.Q., Tang, Z.H., Li, Q.S., Yang, Y., Liu, H.Y., Duan, T.C., Hong, H. and Chen, X.S., Macromol. Biosci., 2012, 12(11): 1514

    Article  CAS  Google Scholar 

  26. Wilson, R., Plummer, R., Adam, J., Eatock, M., Boddy, A., Griffin, M., Miller, R., Matsumura, Y., Shimizu, T. and Calvert, H., J. Clin. Oncol., 2008, 262573

    Google Scholar 

  27. Yu, H., Tang, Z., Song, W., Deng, M. and Chen, X., Chem. J. Chinese U., 2014, 35(5): 903

    CAS  Google Scholar 

  28. Yu, H., Tang, Z., Li, M., Song, W., Zhang, D., Zhang, Y., Yang, Y., Sun, H., Deng, M. and Chen, X., J. Biomed. Nanotechnol., Accepted

  29. Lee, H., Fonge, H., Hoang, B., Reilly, R.M. and Allen, C., Mol. Pharm., 2010, 7(4): 1195

    Article  CAS  Google Scholar 

  30. Bae, Y.H. and Park, K., J. Control. Release, 2011, 153(3): 198

    Article  CAS  Google Scholar 

  31. Nichols, J.W. and Bae, Y.H., J. Control. Release, 2014, 190: 451

    Article  CAS  Google Scholar 

  32. Jain, R.K. and Stylianopoulos, T., Nat. Rev. Clin. Oncol., 2010, 7(11): 653

    Article  CAS  Google Scholar 

  33. Sugahara, K.N., Teesalu, T., Karmali, P.P., Kotamraju, V.R., Agemy, L., Greenwald, D.R. and Ruoslahti, E., Science, 2010, 328(5981): 1031

    Article  CAS  Google Scholar 

  34. Hobbs, S.K., Monsky, W.L., Yuan, F., Roberts, W.G., Griffith, L., Torchilin, V.P. and Jain, R.K., Proc. Natl. Acad. Sci. U.S.A., 1998, 95(8): 4607

    Article  CAS  Google Scholar 

  35. Yuan, F., Dellian, M., Fukumura, D., Leunig, M., Berk, D.A., Torchilin, V.P. and Jain, R.K., Cancer Res., 1995, 55(17): 3752

    CAS  Google Scholar 

  36. Duan, X. and Li, Y., Small, 2013, 9(9–10): 1521

    Article  CAS  Google Scholar 

  37. Venturoli, D. and Rippe, B., Am. J. Physiol. Renal Physiol., 2005, 288(4): F605

    Article  CAS  Google Scholar 

  38. Yuan, F., Semin. Radiat. Oncol., 1998, 8(3): 164

    Article  CAS  Google Scholar 

  39. Wang, Z., Ma, G., Zhang, J., Lin, W., Ji, F., Bernards, M.T. and Chen, S., Langmuir, 2014, 30(13): 3764

    Article  CAS  Google Scholar 

  40. Huang, Y., Tang, Z., Zhang, X., Yu, H., Sun, H., Pang, X. and Chen, X., Biomacromolecules, 2013, 14(6): 2023

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Orthopaedics, the Norman Bethune First Hospital of Jilin University, Changchun, 130021, China

    Yi-fei Li & Jian-guo Liu  (刘建国)

  2. Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China

    Hai-yang Yu, Hai Sun, Zhao-hui Tang  (汤朝晖) & Xue-si Chen

  3. Jilin Central Hospital, Jilin, 132011, China

    Yi-fei Li

  4. Basic Medical College, Beihua University, Jilin, 132013, China

    Dan Wang

  5. The Hospital of Jilin Chemical Industry Company, Jilin, 132021, China

    Lian-you Yu

Authors
  1. Yi-fei Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hai-yang Yu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hai Sun
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jian-guo Liu  (刘建国)
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Zhao-hui Tang  (汤朝晖)
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Dan Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Lian-you Yu
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Xue-si Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Jian-guo Liu  (刘建国) or Zhao-hui Tang  (汤朝晖).

Additional information

This work was financially supported by the National Natural Science Foundation of China (Nos. 51373168, 51233004, 21104076, 51321062 and 51390484), Ministry of Science and Technology of China (International Cooperation and Communication Program 2011DFR51090) and the Program of Scientific Development of Jilin Province (Nos. 20130206066GX, 20130727050YY and 20130521011JH).

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Li, Yf., Yu, Hy., Sun, H. et al. Cisplatin-loaded poly(L-glutamic acid)-g-methoxy poly(ethylene glycol) nanoparticles as a potential chemotherapeutic agent against osteosarcoma. Chin J Polym Sci 33, 763–771 (2015). https://doi.org/10.1007/s10118-015-1624-0

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10118-015-1624-0

Keywords

Search

Navigation