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Efficacy of a single Nd:YAG laser dose in reducing pain after mandibular third molar extraction: a prospective randomized controlled clinical trial

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Abstract

The purpose is to explore the analgesic effect of a single Nd:YAG laser dose after mandibular third molar extraction. This was a prospective randomized controlled clinical trial. Subjects were enrolled according to the inclusion and exclusion criteria and randomly divided into the experimental and control groups. In the experimental group, the wound was irradiated with the Nd:YAG laser (wavelength, 1064 nm; output power, 1.5 W; energy density, 45 J/cm2; and power density, 1.5/cm2, pulsed mode) immediately after mandibular third molar extraction for 120 s (30 s at each site). In the control group, the laser working tip was placed near the extraction site but not activated. The primary outcome was the visual analog scale (VAS) pain scores in both groups at 2, 4, 12, 24, 48, and 72 h and 7 days after surgery. Secondary outcomes included wound healing scores and adverse reactions. The VAS score was significantly lower in the experimental group than in the control group at 2 and 4 h after surgery, while there was no significant difference in the VAS score between the two groups at 12, 24, or 48 h or 7 days after surgery. There were no significant differences in the wound healing scores between the two groups on postoperative day 7. No adverse reactions were observed in any of the laser-irradiated areas. A single Nd:YAG laser dose was effective in reducing pain at 2 and 4 h after mandibular third molar extraction. China Clinical Trial Registry: ChiCTR2000033870 (Registration Date: 2020–6-15).

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Authors and Affiliations

  1. First Clinical Division, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials, No. 22, Zhongguancun South Avenue, Haidian District, Beijing, 100081, PR China

    Tian Meng, Linhai He, Yuhuan Chen & Zhiyong Zhang

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  1. Tian Meng
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  2. Linhai He
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  3. Yuhuan Chen
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  4. Zhiyong Zhang
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Contributions

All authors contributed to the study conception and design. The analysis and first draft of the manuscript was written by Tian Meng. Material preparation and investigation was performed by Linhai He. The data collection was performed by Chen Yuhuan. Methodology was performed by Zhiyong Zhang. All authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Tian Meng.

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Ethics approval and informed consent

Approval was obtained from the ethics committee of Peking University School of Stomatology (PKUSSIRB-202054019). The procedures used in this study adhere to the tenets of the Declaration of Helsinki. Informed consent was obtained from all individual participants included in the study.

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The authors declare no competing interests.

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Meng, T., He, L., Chen, Y. et al. Efficacy of a single Nd:YAG laser dose in reducing pain after mandibular third molar extraction: a prospective randomized controlled clinical trial. Lasers Med Sci 39, 63 (2024). https://doi.org/10.1007/s10103-024-04010-5

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