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The effects of low-level laser therapy on polycystic ovarian syndrome in rats: three different dosages

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Abstract

The main objective of this in vivo study was to investigate the effect of different low-level laser therapy (LLLT) doses on polycystic ovary syndrome (PCOS). In the present experimental study, a single dosage of estradiol valerate (EV) was administered to induce PCOS in female rats. After administration of the EV for induction of PCOS, rats were divided into 5 groups (n = 8/group): C group (animals that were not exposed to any form of procedure), PC group (no treatment following EV induction), L1 group (1 J/cm2 LLLT treatment following EV induction), L2 group (2 J/cm2 LLLT treatment following EV induction), L3 group (6 J/cm2 LLLT treatment following EV induction). The results indicated that no significant difference was found in the serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and progesterone (P4) between the C and L2 groups (p < 0.05). Although the serum levels of testosterone (T) were significantly higher in the C group compared with other groups (p < 0.05), the L2 group was determined to be the closest to the C group. Additionally, the LH, FSH, and T receptor level of the L2 group was closest to the C group. In conclusion, a 2 J/cm2 dosage of LLLT (L2 group) can be considered the most potentially effective treatment of PCOS in the rat. However, more studies are needed to determine the optimal dose of LLLT for the treatment of PCOS.

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Data availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Funding

This study received support from Atatürk University Scientific Research Projects (TSA-2019-7440).

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Faculty Veterinary Medicine, Atatürk University, Erzurum, Turkey

    Bülent Polat, Damla Tuğçe Okur & Armağan Çolak

  2. BIL-TEC, TEKNOKENT, TR-25240, Erzurum, Turkey

    Bülent Polat

  3. Celal Oruç Animal Production School, Ağrı İbrahim Çeçen University, Ağrı, Turkey

    Kader Yilmaz

  4. Department of Pathology, Faculty Veterinary Medicine, Sivas Cumhuriyet University, Sivas, Turkey

    Mustafa Özkaraca

  5. Department of Pathology, Faculty Veterinary Medicine, Atatürk University, Erzurum, Turkey

    Selim Çomakli

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  1. Bülent Polat
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Bülent Polat, Damla Tuğçe Okur: literature search, study design, data collection and interpretation, and manuscript preparation. Damla Tuğçe Okur, Armağan Çolak, Kader Yilmaz: statistical analysis, data collection, interpretation, and manuscript preparation. Selim Çomaklı, Mustafa Özkaraca: histopathological analysis and evaluation.

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Correspondence to Damla Tuğçe Okur.

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Polat, B., Okur, D.T., Çolak, A. et al. The effects of low-level laser therapy on polycystic ovarian syndrome in rats: three different dosages. Lasers Med Sci 38, 177 (2023). https://doi.org/10.1007/s10103-023-03847-6

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